SLC4A2 and GET1

Data Source: HiPPIP (Novel)

		SLC4A2	GET1
Name		solute carrier family 4 member 2	guided entry of tail-anchored proteins factor 1
Structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Antiporter Activity Enzyme Binding Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity	Protein Binding Protein-membrane Adaptor Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Spermatogenesis Inorganic Anion Transport Bicarbonate Transport Osteoclast Differentiation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Bone Resorption Digestive Tract Development Regulation Of Intracellular PH Transmembrane Transport Positive Regulation Of Enamel Mineralization Amelogenesis Monoatomic Anion Transmembrane Transport Chloride Transmembrane Transport Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane
Pathways		Bicarbonate transporters	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
GWAS		Eyebrow thickness ( 26926045 ) Heel bone mineral density ( 30598549 ) Mean corpuscular hemoglobin ( 32888494 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GET1	6 novel interactors: BOC GATD3 PDXK SCN3A SLC4A2 TRAPPC10
Interacting Genes		3 interacting genes: ATXN1 CA2 EPB42	28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42
Entrez ID		6522	7485
HPRD ID		02728	04224
Ensembl ID		ENSG00000164889	ENSG00000182093
Uniprot IDs		P04920 Q59GF1	O00258
PDB IDs		8GV8 8GV9 8GVA 8GVC 8GVE 8GVF 8GVH 8JNI 8JNJ 8ZLE	6SO5 8CQZ 8CR1 8CR2
GO Terms Enriched among Interactors		Regulation Of Biological Quality Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity GET Complex Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Chloride Transport POZ Domain Binding Ankyrin-1 Complex Protein-glutamine Gamma-glutamyltransferase Activity Poly(G) Binding Otic Vesicle Development Animal Organ Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Hemoglobin Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nuclear Inclusion Body Regulation Of Monoatomic Anion Transport Carbonate Dehydratase Activity Carbon Dioxide Transport Positive Regulation Of Synaptic Transmission, GABAergic Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Angiotensin-activated Signaling Pathway Erythrocyte Maturation Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway One-carbon Compound Transport Multicellular Organismal-level Iron Ion Homeostasis Myelin Sheath Cortical Cytoskeleton Protein Targeting To ER Protein Insertion Into ER Membrane Regulation Of Synaptic Transmission, GABAergic Developmental Process Insulin-like Growth Factor Receptor Signaling Pathway Protein-membrane Adaptor Activity Establishment Of Protein Localization To Endoplasmic Reticulum	Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex