SLC4A2 and EPB42

Number of citations of the paper that reports this interaction (PubMedID 7626035)
23

Data Source:
HPRD (in vitro)

		SLC4A2	EPB42
Description		solute carrier family 4 member 2	erythrocyte membrane protein band 4.2
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Cytoplasm Cytoskeleton Plasma Membrane Membrane Cortical Cytoskeleton Cell Periphery Ankyrin-1 Complex
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Antiporter Activity Enzyme Binding Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Spermatogenesis Inorganic Anion Transport Bicarbonate Transport Osteoclast Differentiation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Bone Resorption Digestive Tract Development Regulation Of Intracellular PH Transmembrane Transport Positive Regulation Of Enamel Mineralization Amelogenesis Monoatomic Anion Transmembrane Transport Chloride Transmembrane Transport Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Cell Morphogenesis Cytoskeleton Organization Regulation Of Cell Shape Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Monoatomic Ion Homeostasis Multicellular Organismal-level Iron Ion Homeostasis
Pathways		Bicarbonate transporters
Drugs
Diseases			Hereditary spherocytosis (SPH)
GWAS		Eyebrow thickness ( 26926045) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		3 interacting genes: ATXN1 CA2 EPB42	13 interacting genes: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12
Entrez ID		6522	2038
HPRD ID		02728	01517
Ensembl ID		ENSG00000164889	ENSG00000166947
Uniprot IDs		P04920 Q59GF1	P16452
PDB IDs		8GV8 8GV9 8GVA 8GVC 8GVE 8GVF 8GVH 8JNI 8JNJ 8ZLE	7TVZ 7TW0 7TW1 7TW3 7TW5 7TW6 7UZS 7V0K 7V0Q 8CS9 8CSL 8CSW 8CTE
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity GET Complex Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Chloride Transport POZ Domain Binding Ankyrin-1 Complex Protein-glutamine Gamma-glutamyltransferase Activity Poly(G) Binding Otic Vesicle Development Animal Organ Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Hemoglobin Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nuclear Inclusion Body Regulation Of Monoatomic Anion Transport Carbonate Dehydratase Activity Carbon Dioxide Transport Positive Regulation Of Synaptic Transmission, GABAergic Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Angiotensin-activated Signaling Pathway Erythrocyte Maturation Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway One-carbon Compound Transport Multicellular Organismal-level Iron Ion Homeostasis Myelin Sheath Cortical Cytoskeleton Protein Targeting To ER Protein Insertion Into ER Membrane Regulation Of Synaptic Transmission, GABAergic Developmental Process Insulin-like Growth Factor Receptor Signaling Pathway Protein-membrane Adaptor Activity Establishment Of Protein Localization To Endoplasmic Reticulum	Spectrin Binding Spectrin-associated Cytoskeleton Structural Constituent Of Cytoskeleton Basolateral Plasma Membrane Cortical Cytoskeleton Regulation Of Actin Filament-based Process Ankyrin-1 Complex Monoatomic Anion Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Cytoskeleton Organization A Band BLOC-1 Complex Cytoplasmic Side Of Plasma Membrane Regulation Of Actin Cytoskeleton Organization Z Disc Cytoskeletal Anchor Activity Actin Cytoskeleton Organization Organelle Organization Enzyme Binding M Band Intracellular Monoatomic Ion Homeostasis Regulation Of Biological Quality Intracellular Monoatomic Cation Homeostasis Homeostatic Process Actin Filament-based Process Bicarbonate Transport Erythrocyte Development Actin Filament Capping Protein-membrane Adaptor Activity Monoatomic Cation Homeostasis Protein Localization To Plasma Membrane Monoatomic Ion Homeostasis Negative Regulation Of Actin Filament Depolymerization Localization Within Membrane Intracellular Chemical Homeostasis Regulation Of Cytoskeleton Organization Osteoclast Differentiation Protein Localization To Cell Periphery Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Protein Localization To T-tubule PH Elevation Regulation Of Actin Filament Organization Endomembrane System Cellular Homeostasis Regulation Of Interleukin-12 Production Myeloid Cell Development Cytoskeletal Protein Binding Regulation Of Organelle Organization
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