RTN4R and NGFR

Number of citations of the paper that reports this interaction (PMID 12422217)
119

Data Source:
HPRD (in vivo, in vitro)

		RTN4R	NGFR
Gene Name		reticulon 4 receptor	nerve growth factor receptor
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell Surface Growth Cone Anchored Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density
	Molecular Function	Receptor Activity Protein Binding	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding
	Biological Process	Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling	Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: LINGO1 MAG NGFR OMG RTN4 RTN4IP1	45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274
Entrez ID		65078	4804
HPRD ID		16123	01197
Ensembl ID		ENSG00000040608	ENSG00000064300
Uniprot IDs		Q9BZR6	P08138
PDB IDs		1OZN 1P8T	3EWV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Axonogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Projection Organization Regulation Of Axonogenesis Negative Regulation Of Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Neurogenesis Negative Regulation Of Cell Development Regulation Of Neuron Projection Development Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Regulation Of Neuron Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Cell Differentiation Regulation Of Cell Development Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Regulation Of Cell Differentiation Neurogenesis Cellular Response To Organic Substance Neuron Projection Development Regulation Of Cellular Component Organization Neuron Development Central Nervous System Development Nervous System Development Neuron Differentiation Response To Organic Substance Cell Projection Organization Cell Surface Receptor Signaling Pathway Cell Differentiation Cell Development Regulation Of Cell Size Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Hair Follicle Development Regulation Of Branching Morphogenesis Of A Nerve System Development Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Hair Cycle Multicellular Organismal Development Endoplasmic Reticulum Tubular Network Organization Anatomical Structure Development Regulation Of Developmental Growth Signal Transduction Locomotion Positive Regulation Of Odontogenesis	Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud ?			acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Difference) ?			acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Intersection) ?