RTN4R and RTN4IP1

Number of citations of the paper that reports this interaction (PubMedID 12160746)
0

Data Source:
HPRD (in vitro)

		RTN4R	RTN4IP1
Description		reticulon 4 receptor	reticulon 4 interacting protein 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Axon Dendrite Growth Cone Cell Projection Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Membrane
	Molecular Function	Protein Binding Heparin Binding Lipid Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding	Nucleotide Binding Protein Binding Zinc Ion Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Axonogenesis Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Regulation Of Synapse Assembly Regulation Of Postsynapse Assembly	Ubiquinone Biosynthetic Process Nervous System Development Regulation Of Dendrite Development
Pathways		Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Obesity-related traits ( 23251661)	Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: HOXA1 LINGO1 MAG MGAT5B NGFR OMG OTX1 RTN4 RTN4IP1	23 interacting genes: ARFGAP3 CALCOCO2 CBFA2T3 CENPK CTAG1A CTAG1B ERMN EXOC7 GGA2 HDX MARCHF5 PPP1R8 PYM1 RELA RTN4 RTN4R RUNX1T1 SCAF1 SMURF2 SORBS1 WBP11 WWTR1 ZYX
Entrez ID		65078	84816
HPRD ID		16123	18008
Ensembl ID		ENSG00000040608	ENSG00000130347
Uniprot IDs		Q9BZR6	Q8WWV3
PDB IDs		1OZN 1P8T	2VN8
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Cochlea Morphogenesis Blood Vessel Development Neuron Projection Regeneration Regulation Of Neuron Projection Development Negative Regulation Of Axon Extension Artery Development Semicircular Canal Formation Developmental Process Negative Regulation Of Axonogenesis Nervous System Development Diencephalon Morphogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Coreceptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Abducens Nerve Formation Optokinetic Behavior Mesaxon Regulation Of Cell Projection Organization Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Regulation Of Axon Extension Ganglioside GT1b Binding Death Receptor Activity Metencephalon Development Positive Regulation Of Protein Localization To Endoplasmic Reticulum	RNA Metabolic Process
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