KLC2 and MAPK8IP3

Number of citations of the paper that reports this interaction (PMID 11106729)
76

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		KLC2	MAPK8IP3
Gene Name		kinesin light chain 2	mitogen-activated protein kinase 8 interacting protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Kinesin I Complex Ciliary Rootlet Neuron Projection Protein Complex	Golgi Membrane Cytoplasm Smooth Endoplasmic Reticulum Dendrite Axolemma
	Molecular Function	Microtubule Motor Activity Protein Binding Kinesin Binding	MAP-kinase Scaffold Activity JUN Kinase Binding Kinesin Binding Receptor Signaling Complex Scaffold Activity Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Microtubule-based Movement Blood Coagulation Axon Cargo Transport Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	In Utero Embryonic Development Activation Of JUN Kinase Activity Axon Guidance Respiratory Gaseous Exchange Protein Localization Post-embryonic Development Regulation Of Gene Expression Vesicle-mediated Transport Forebrain Development Positive Regulation Of Neuron Differentiation Regulation Of JNK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways		MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		12 interactors: AIMP2 APP CLSTN1 COIL KIF2A KLC1 MAPK8IP3 PIK3R3 S100A8 YWHAG YWHAQ YWHAZ	21 interactors: ARL4D CASP3 KLC1 KLC2 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAF1 RIC8A SRC TLR2 TLR4 TLR9
Entrez ID		64837	23162
HPRD ID		13917	12014
Ensembl ID		ENSG00000174996	ENSG00000138834
Uniprot IDs		Q9H0B6	E9PFH7 Q9UPT6
PDB IDs		3CEQ 3EDT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Mitochondrion Organization Cell Death Death Wound Healing Response To Wounding Regulation Of Mitochondrion Organization Blood Coagulation Hemostasis Intrinsic Apoptotic Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Axon Cargo Transport Movement Of Cell Or Subcellular Component Regulation Of Kinase Activity Microtubule-based Movement Intracellular Transport Apoptotic Signaling Pathway Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Targeting Regulation Of Intracellular Transport Neutrophil Aggregation Synaptic Growth At Neuromuscular Junction Stress Granule Disassembly Protein Localization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Microtubule-based Transport Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Immune System Process	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade JNK Cascade Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Kinase Activity Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAP Kinase Activity Response To Stress Positive Regulation Of Innate Immune Response Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Toll-like Receptor 9 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
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