KLC2 and RUSC2

Number of citations of the paper that reports this interaction (PubMedID 34432492)
91

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		KLC2	RUSC2
Description		kinesin light chain 2	RUN and SH3 domain containing 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Cytosol Cytoskeleton Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Kinesin Binding Cadherin Binding	Protein Binding Small GTPase Binding
	Biological Process	Microtubule-based Movement Lysosome Localization
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)	Psoriasis ( 25903422)
Interacting Genes		17 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 KIF2A KLC1 LRRK2 MAPK8IP3 PIK3R3 PRC1 RUSC2 S100A8 TRIB1 YWHAG YWHAQ YWHAZ	11 interacting genes: DLST EGFR FXR1 GIT2 GOLGA2 KHDRBS1 KLC2 MAGEC1 RAB1A RAB1B SRPRA
Entrez ID		64837	9853
HPRD ID		13917	18009
Ensembl ID		ENSG00000174996	ENSG00000198853
Uniprot IDs		Q9H0B6	Q8N2Y8
PDB IDs		3CEQ 3EDT	6IF2
Enriched GO Terms of Interacting Partners?		Kinesin Binding Cytosol Microtubule Binding Growth Cone Transmembrane Transporter Binding Cytoskeletal Motor Activity Cellular Response To Manganese Ion Microtubule-based Movement RAGE Receptor Binding Response To Manganese Ion Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Microtubule-based Process Response To Catecholamine Intracellular Signaling Cassette Regulation Of Synapse Organization Intracellular Signal Transduction Regulation Of Synapse Maturation Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Regulation Of Immune System Process Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Transport Along Microtubule Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Regulation Of CAMP/PKA Signal Transduction Regulation Of Programmed Cell Death Cytoplasm Regulation Of MAPK Cascade Microtubule Vesicle Spindle Pole Kinesin Complex Spindle Microtubule S100A8 Complex Cellular Response To Starvation Regulation Of Protein Stability Protein Sequestering Activity X11-like Protein Binding Signaling Receptor Complex Adaptor Activity Cellular Response To Curcumin Caveola Neck	Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Protein Metabolic Process Virion Assembly Cadherin Binding Establishment Of Endothelial Intestinal Barrier Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Protein Metabolic Process Establishment Of Endothelial Barrier Endothelial Cell Development Dihydrolipoyllysine-residue Succinyltransferase Activity Multivesicular Body, Internal Vesicle Lumen Grb2-Sos Complex Kinesin I Complex Golgi Membrane Golgi Vesicle Transport Establishment Of Protein Localization Organelle Assembly G Protein Activity GTPase Activity Shc-EGFR Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Oxoadipate Dehydrogenase Complex Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Catabolic Process Epidermal Growth Factor Receptor Activity Autophagosome Assembly GTP Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Autophagosome Organization L-lysine Catabolic Process Membrane Epidermal Growth Factor Binding Positive Regulation Of Protein Glycosylation Establishment Of Localization In Cell Signal Recognition Particle Receptor Complex
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