KLC2 and AIMP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KLC2	AIMP2
Gene Name		kinesin light chain 2	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Kinesin I Complex Ciliary Rootlet Neuron Projection Protein Complex	Nucleus Cytosol Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding Kinesin Binding	Protein Binding
	Biological Process	Microtubule-based Movement Blood Coagulation Axon Cargo Transport Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	TRNA Aminoacylation For Protein Translation Apoptotic Process Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Protein Ubiquitination Type II Pneumocyte Differentiation
Pathways		MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		12 interactors: AIMP2 APP CLSTN1 COIL KIF2A KLC1 MAPK8IP3 PIK3R3 S100A8 YWHAG YWHAQ YWHAZ	48 interactors: ACTB AIMP1 APP BCAS2 BLOC1S4 BYSL C19orf57 CEP170P1 CHD3 DARS DARS2 DEAF1 DSN1 EPRS EPS8 FGB FHL3 FUBP1 GYS1 ICE1 KARS KDR KIAA1377 KLC2 LMO2 LMO3 LNX1 LUC7L2 MATR3 MCF2L MIS18A NDEL1 NECAB2 NGFRAP1 PARK2 PCMT1 PLEKHF2 PPP2R1A PRKAA2 PSME1 TANK TERF2IP TFIP11 TP53 TRAF2 TRMT2A ZC3H12A ZGPAT
Entrez ID		64837	7965
HPRD ID		13917	02915
Ensembl ID		ENSG00000174996	ENSG00000106305
Uniprot IDs		Q9H0B6	A8MU58 Q13155
PDB IDs		3CEQ 3EDT	4DPG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Mitochondrion Organization Cell Death Death Wound Healing Response To Wounding Regulation Of Mitochondrion Organization Blood Coagulation Hemostasis Intrinsic Apoptotic Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Axon Cargo Transport Movement Of Cell Or Subcellular Component Regulation Of Kinase Activity Microtubule-based Movement Intracellular Transport Apoptotic Signaling Pathway Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Targeting Regulation Of Intracellular Transport Neutrophil Aggregation Synaptic Growth At Neuromuscular Junction Stress Granule Disassembly Protein Localization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Microtubule-based Transport Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Immune System Process	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Component Assembly TRNA Aminoacylation For Protein Translation Axon Cargo Transport TRNA Aminoacylation Cell Cycle Process NcRNA Metabolic Process Mitotic Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Autophagy Mitotic Cell Cycle Apoptotic Process Platelet Aggregation Negative Regulation Of Reactive Oxygen Species Metabolic Process Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Mitochondrion Degradation Protein Complex Assembly Microtubule-based Transport Immune System Process Cell Death Death TRNA Metabolic Process Cellular Response To Organic Substance Cytoskeleton-dependent Intracellular Transport Blood Coagulation Cell Cycle Cellular Macromolecule Biosynthetic Process Hemostasis Positive Regulation Of Peptidase Activity Macromolecule Biosynthetic Process Cellular Process Cellular Amino Acid Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cellular Metabolic Process Response To Wounding Regulation Of Signaling Regulation Of Cellular Ketone Metabolic Process
Tagcloud ?			4x20 abl abrogated bbb c57 compacts dopaminergic e3 easily endothelium inno irreversible microvessel mitigated mptp nanomolar neurodegeneration neuroprotective nigra nitrative parkin pars pd pharmacokinetic striatum substantia th translated ubiquitously
Tagcloud (Difference) ?			4x20 abl abrogated bbb c57 compacts dopaminergic e3 easily endothelium inno irreversible microvessel mitigated mptp nanomolar neurodegeneration neuroprotective nigra nitrative parkin pars pd pharmacokinetic striatum substantia th translated ubiquitously
Tagcloud (Intersection) ?