KLC2 and PIK3R3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KLC2	PIK3R3
Gene Name		kinesin light chain 2	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Kinesin I Complex Ciliary Rootlet Neuron Projection Protein Complex	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Microtubule Motor Activity Protein Binding Kinesin Binding	Protein Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Regulator Activity
	Biological Process	Microtubule-based Movement Blood Coagulation Axon Cargo Transport Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process
Pathways		MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Costimulation by the CD28 family PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		12 interactors: AIMP2 APP CLSTN1 COIL KIF2A KLC1 MAPK8IP3 PIK3R3 S100A8 YWHAG YWHAQ YWHAZ	38 interactors: ABCB6 AMBP AXL DARS DRAP1 DSN1 EGFR ERBB2 ERBB3 ESR1 FBN3 FGB FSD2 GC IGF1R INSR IRS1 IRS2 KARS KHDRBS1 KIAA1377 KLC2 L3MBTL3 LUC7L2 MBIP MICAL1 ORM1 PDGFRB PIK3CA PSME1 QARS RB1 RING1 SERF1A TEC TRIM54 TRMT2A VBP1
Entrez ID		64837	8503
HPRD ID		13917	05831
Ensembl ID		ENSG00000174996	ENSG00000117461
Uniprot IDs		Q9H0B6	F6TDL0 Q8N381 Q92569
PDB IDs		3CEQ 3EDT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Mitochondrion Organization Cell Death Death Wound Healing Response To Wounding Regulation Of Mitochondrion Organization Blood Coagulation Hemostasis Intrinsic Apoptotic Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Axon Cargo Transport Movement Of Cell Or Subcellular Component Regulation Of Kinase Activity Microtubule-based Movement Intracellular Transport Apoptotic Signaling Pathway Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Targeting Regulation Of Intracellular Transport Neutrophil Aggregation Synaptic Growth At Neuromuscular Junction Stress Granule Disassembly Protein Localization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Microtubule-based Transport Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Immune System Process	Phosphatidylinositol-mediated Signaling Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Innate Immune Response Immune System Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cell Death Cellular Response To Hormone Stimulus Positive Regulation Of Signal Transduction Wound Healing Positive Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Defense Response Organ Development Negative Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Regulation Of Signaling Response To Wounding Protein Autophosphorylation Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Peptidyl-amino Acid Modification
Tagcloud ?			akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying
Tagcloud (Difference) ?			akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying
Tagcloud (Intersection) ?