KLC2 and DDX41

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		KLC2	DDX41
Description		kinesin light chain 2	DEAD-box helicase 41
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Cytosol Cytoskeleton Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Endoplasmic Reticulum Cytosol Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Kinesin Binding Cadherin Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Microtubule-based Movement Lysosome Localization	MRNA Splicing, Via Spliceosome MRNA Processing Apoptotic Process Cell Population Proliferation RNA Splicing Cell Differentiation Positive Regulation Of Type I Interferon Production Cellular Response To Interferon-beta Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus CGAS/STING Signaling Pathway
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 KIF2A KLC1 LRRK2 MAPK8IP3 PIK3R3 PRC1 RUSC2 S100A8 TRIB1 YWHAG YWHAQ YWHAZ	11 interacting genes: AIDA CEBPA CEP70 CHAF1A KLC2 NKAPL OGT SIAH1 TRIM26 TRIM41 TUBG1
Entrez ID		64837	51428
HPRD ID		13917	10490
Ensembl ID		ENSG00000174996	ENSG00000183258
Uniprot IDs		Q9H0B6	B3KRK2 Q9UJV9
PDB IDs		3CEQ 3EDT	2P6N 5GVR 5GVS 5H1Y 8C6J
Enriched GO Terms of Interacting Partners?		Kinesin Binding Cytosol Microtubule Binding Growth Cone Transmembrane Transporter Binding Cytoskeletal Motor Activity Cellular Response To Manganese Ion Microtubule-based Movement RAGE Receptor Binding Response To Manganese Ion Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Microtubule-based Process Response To Catecholamine Intracellular Signaling Cassette Regulation Of Synapse Organization Intracellular Signal Transduction Regulation Of Synapse Maturation Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Regulation Of Immune System Process Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Transport Along Microtubule Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Regulation Of CAMP/PKA Signal Transduction Regulation Of Programmed Cell Death Cytoplasm Regulation Of MAPK Cascade Microtubule Vesicle Spindle Pole Kinesin Complex Spindle Microtubule S100A8 Complex Cellular Response To Starvation Regulation Of Protein Stability Protein Sequestering Activity X11-like Protein Binding Signaling Receptor Complex Adaptor Activity Cellular Response To Curcumin Caveola Neck
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?