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RFWD2 and YWHAZ
Number of citations of the paper that reports this interaction (PMID
20843328
)
6
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology)
RFWD2
YWHAZ
Gene Name
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Focal Adhesion
Nuclear Speck
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Focal Adhesion
Postsynaptic Density
Cytoplasmic Vesicle Membrane
Cell Leading Edge
Melanosome
Mast Cell Granule
Protein Complex
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Blood Microparticle
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein Complex Binding
Identical Protein Binding
Poly(A) RNA Binding
Biological Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Response To Ionizing Radiation
Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Histamine Secretion By Mast Cell
Protein Targeting To Mitochondrion
Apoptotic Process
Signal Transduction
Blood Coagulation
Gene Expression
Platelet Activation
Response To Drug
Negative Regulation Of Apoptotic Process
Establishment Of Golgi Localization
Membrane Organization
Golgi Reassembly
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
p53-Dependent G1 DNA Damage Response
Autodegradation of the E3 ubiquitin ligase COP1
Stabilization of p53
Cell Cycle Checkpoints
p53-Dependent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Translocation of GLUT4 to the plasma membrane
Activation of BH3-only proteins
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
Rap1 signalling
RNF mutants show enhanced WNT signaling and proliferation
Programmed Cell Death
XAV939 inhibits tankyrase, stabilizing AXIN
Intrinsic Pathway for Apoptosis
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Cytokine Signaling in Immune system
Activation of BAD and translocation to mitochondria
Signaling by Interleukins
TCF dependent signaling in response to WNT
KSRP destabilizes mRNA
GP1b-IX-V activation signalling
Signaling by WNT in cancer
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Adaptive Immune System
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Protein-Protein Interactions
14 interactors:
CCT4
DET1
ETS1
ETS2
JUN
JUND
PTPN1
RB1CC1
SFN
SIPA1
TP53
UBE2D1
UBE2D2
YWHAZ
191 interactors:
AANAT
ABL1
ADAM22
ADRA2A
ADRA2B
ADRA2C
AKAP13
AKT1
APP
ARAF
ARHGEF2
ATP5A1
ATXN1
BAD
BCAR1
BCR
BRAF
BSPRY
CBL
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CENPJ
CFL1
CGNL1
CLIC4
CRTC2
CSF2RB
CSNK1A1
CSNK1D
DFFA
DISC1
EFNB3
EGFR
EIF3A
ENO1
EPB41L1
EPB41L2
EPB41L3
EXO1
FAM13B
FAM53C
FHOD1
FOXO1
FOXO3
FOXO4
GABARAPL2
GABBR1
GCH1
GP1BA
GP1BB
GP5
HDAC4
HDAC9
HIST1H3A
HIVEP2
HMGN1
HSPA1A
HSPA1B
IGF1R
IL9R
ING1
INPP5A
IRS1
IRS2
KCNK15
KCNK3
KCNK9
KIAA0232
KIAA0930
KIAA1377
KIF1C
KIF5B
KLC2
KLC4
KLF11
KRT18
KSR1
LARP1
LCP2
LIMK1
LRMP
LYST
MADD
MAP2K5
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAPK8
MAPKAPK2
MAPT
MARK2
MARK3
MARK4
MDM4
MEF2C
MINK1
MLF1
MPHOSPH9
MSL2
MST1R
MYH9
NEDD4L
NFATC2
NFATC4
NR4A1
PAK1
PAK4
PARD3
PARD6A
PARD6B
PDC
PFKFB2
PIAS1
PPP1CC
PPP1R14A
PRDX2
PRKCA
PRKCD
PRKCI
PRKCZ
PRKD1
PRLR
PRMT5
PSMA5
PTPN13
PTPRO
RAF1
RALGPS2
RAP1GAP2
RASAL3
REM1
RFWD2
RGS3
RIN1
RMDN3
RPRD1A
RRAD
SAMSN1
SH3GL1
SIK1
SIK3
SIMC1
SLC8A2
SNX24
SORBS2
SQSTM1
SSFA2
SSX2IP
STK25
STK38
SYN2
SYNPO
SYNPO2
TAB2
TBXA2R
TERT
TH
TJP2
TLK2
TNFAIP3
TNS1
TP53
TPD52L1
TPH1
TRA2B
TRIM21
TSC1
TSC2
TUBB
UBC
UBE3A
UCHL5
UCP2
UCP3
VCP
VIM
WEE1
WNK1
WNK2
WWTR1
XRCC6
YWHAE
ZAK
ZNF839
Entrez ID
64326
7534
HPRD ID
07455
03183
Ensembl ID
ENSG00000143207
ENSG00000164924
Uniprot IDs
Q05CT6
Q8NHY2
D0PNI1
P63104
PDB IDs
1IB1
1QJA
1QJB
2C1J
2C1N
2O02
2WH0
3CU8
3NKX
3RDH
4BG6
4FJ3
4HKC
4IHL
Enriched GO Terms of Interacting Partners
?
Cellular Response To Stress
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Response To Abiotic Stimulus
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Stress
Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Transcription From RNA Polymerase II Promoter
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Mitochondrion Organization
Cellular Response To Extracellular Stimulus
Regulation Of Cell Cycle
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Apoptotic Mitochondrial Changes
Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Response To Hypoxia
Regulation Of Mitochondrion Organization
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Hypoxia
Intracellular Signal Transduction
Cellular Response To Decreased Oxygen Levels
Response To Wounding
Regulation Of Cellular Component Organization
Toll-like Receptor Signaling Pathway
Apoptotic Signaling Pathway
Cellular Response To Oxygen Levels
Cellular Response To Stimulus
Mitochondrion Organization
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Immune System Process
Cellular Response To Starvation
Transforming Growth Factor Beta Receptor Signaling Pathway
Activation Of Innate Immune Response
Regulation Of Apoptotic Process
Organelle Organization
RNA Metabolic Process
Transcription, DNA-templated
Negative Regulation Of Cell Cycle
Negative Regulation Of Apoptotic Process
Regulation Of Cell Death
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Programmed Cell Death
Response To Extracellular Stimulus
Intracellular Signal Transduction
Cell Communication
Regulation Of Phosphorylation
Cellular Response To Stimulus
Regulation Of Phosphorus Metabolic Process
Signaling
Regulation Of Cellular Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Protein Metabolic Process
Response To Stimulus
Signal Transduction
Regulation Of Kinase Activity
Regulation Of Cellular Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Protein Phosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Protein Kinase Activity
Response To Stress
Cellular Response To Growth Factor Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Protein Phosphorylation
Neurotrophin Signaling Pathway
Response To Growth Factor
Positive Regulation Of Cellular Metabolic Process
Cellular Protein Modification Process
Response To Organic Substance
Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Phosphorylation
Cellular Response To Organic Substance
Regulation Of Metabolic Process
Positive Regulation Of Catalytic Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Death
Regulation Of MAPK Cascade
Apoptotic Process
Cell Death
Death
Programmed Cell Death
Positive Regulation Of Protein Modification Process
Phosphate-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Innate Immune Response
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Tagcloud
?
actb
arfgap2
arl1
bestkeeper
bmi1
casc3
cynomolgus
ddx3x
gapdh
genorm
lists
monkey
morf4
mrfap1
normalization
normfinder
ormdl1
prerequisite
reference
ribosylation
rps19
rsl24d1
sar1a
traditionally
transcriptome
usp22
vitally
zc3h11a
zranb2
Tagcloud (Difference)
?
actb
arfgap2
arl1
bestkeeper
bmi1
casc3
cynomolgus
ddx3x
gapdh
genorm
lists
monkey
morf4
mrfap1
normalization
normfinder
ormdl1
prerequisite
reference
ribosylation
rps19
rsl24d1
sar1a
traditionally
transcriptome
usp22
vitally
zc3h11a
zranb2
Tagcloud (Intersection)
?