RFWD2 and RB1CC1

Number of citations of the paper that reports this interaction (PMID 23289756)
0

Data Source:
BioGRID (protein complementation assay)

		RFWD2	RB1CC1
Gene Name		ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	RB1-inducible coiled-coil 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Centrosome Cytosol Focal Adhesion Nuclear Speck	Cytoplasm Cytosol Nuclear Membrane Pre-autophagosomal Structure Membrane ATG1/UKL1 Signaling Complex ULK1-ATG13-FIP200 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Protein Kinase Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Autophagic Vacuole Assembly Liver Development Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle JNK Cascade Heart Development Regulation Of Autophagy Positive Regulation Of Cell Size Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		p53-Dependent G1 DNA Damage Response Autodegradation of the E3 ubiquitin ligase COP1 Stabilization of p53 Cell Cycle Checkpoints p53-Dependent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CCT4 DET1 ETS1 ETS2 JUN JUND PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ	9 interactors: CALCOCO2 EXOC1 GABARAP PTK2 PTK2B RFWD2 TBKBP1 UBC VHL
Entrez ID		64326	9821
HPRD ID		07455	06019
Ensembl ID		ENSG00000143207	ENSG00000023287
Uniprot IDs		Q05CT6 Q8NHY2	Q8TDY2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Response To Abiotic Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Transcription From RNA Polymerase II Promoter Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Mitochondrion Organization Cellular Response To Extracellular Stimulus Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Regulation Of Mitochondrion Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Wounding Regulation Of Cellular Component Organization Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Stimulus Mitochondrion Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Cellular Response To Starvation Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Organelle Organization RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Endoplasmic Reticulum Stress Negative Regulation Of Programmed Cell Death Response To Extracellular Stimulus	Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Stress Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Signal Complex Assembly Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Protein Ubiquitination Immune Response Defense Response Regulation Of Proteolysis Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphatidylinositol 3-kinase Activity Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Lipid Kinase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Negative Regulation Of Apoptotic Process Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Programmed Cell Death Endothelial Cell Migration Apoptotic Process Negative Regulation Of Cell Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Programmed Cell Death Positive Regulation Of Cell Cycle Arrest Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Death Response To Abiotic Stimulus Epithelial Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Epithelium Migration Signal Transduction In Response To DNA Damage Immune System Process Positive Regulation Of Protein Kinase Activity Mitotic DNA Damage Checkpoint
Tagcloud ?			bag3 broiler chicken chickens clusters cytoskeleton degs depth differentially discovered enrichment exact exploited fully gallus heat hsp25 hsph1 hunger id1 leg microarrays modules networks pdk qrt suffering thermoregulation yellow
Tagcloud (Difference) ?			bag3 broiler chicken chickens clusters cytoskeleton degs depth differentially discovered enrichment exact exploited fully gallus heat hsp25 hsph1 hunger id1 leg microarrays modules networks pdk qrt suffering thermoregulation yellow
Tagcloud (Intersection) ?