RFWD2 and JUND

Number of citations of the paper that reports this interaction (PMID 12615916)
22

Data Source:
HPRD (in vivo)

		RFWD2	JUND
Gene Name		ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	jun D proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Centrosome Cytosol Focal Adhesion Nuclear Speck	Chromatin Nucleus Nucleoplasm Protein Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Enzyme Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Osteoblast Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Aging Circadian Rhythm Response To Light Stimulus Response To Mechanical Stimulus Response To Organic Cyclic Compound Response To Lipopolysaccharide Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Calcium Ion
Pathways		p53-Dependent G1 DNA Damage Response Autodegradation of the E3 ubiquitin ligase COP1 Stabilization of p53 Cell Cycle Checkpoints p53-Dependent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CCT4 DET1 ETS1 ETS2 JUN JUND PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ	29 interactors: ACTR3 ATF3 BATF BCL6 BRCA1 COPS5 DDIT3 EP300 ESR1 FOS FOSB FOSL2 HINFP JDP2 LINC00461 MAPK1 MAPK3 MAPK8 MAPK9 MDM2 MEN1 NFE2L1 NFE2L2 PPARG RFWD2 SLC25A12 SMAD3 SMAD4 TBP
Entrez ID		64326	3727
HPRD ID		07455	01304
Ensembl ID		ENSG00000143207	ENSG00000130522
Uniprot IDs		Q05CT6 Q8NHY2	P17535
PDB IDs			3U86
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Response To Abiotic Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Transcription From RNA Polymerase II Promoter Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Mitochondrion Organization Cellular Response To Extracellular Stimulus Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Regulation Of Mitochondrion Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Wounding Regulation Of Cellular Component Organization Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Stimulus Mitochondrion Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Cellular Response To Starvation Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Organelle Organization RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Endoplasmic Reticulum Stress Negative Regulation Of Programmed Cell Death Response To Extracellular Stimulus	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Response To Abiotic Stimulus Macromolecule Biosynthetic Process RNA Metabolic Process Response To Organic Substance Response To Stress Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Response To Lipid Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Cell Death Death Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Response To Organic Cyclic Compound
Tagcloud ?			acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs krox lose medial microglial mystery ngfr parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Difference) ?			acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs krox lose medial microglial mystery ngfr parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Intersection) ?