COP1 and DET1

Number of citations of the paper that reports this interaction (PubMedID 37390815)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		COP1	DET1
Description		COP1 E3 ubiquitin ligase	DET1 partner of COP1 E3 ubiquitin ligase
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Nucleus Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Assembly
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Menarche (age at onset) ( 25231870) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		17 interacting genes: CDKN1B CUL4B DET1 ETS1 ETS2 GATA2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ	2 interacting genes: COP1 DDB1
Entrez ID		64326	55070
HPRD ID		07455	13140
Ensembl ID		ENSG00000143207	ENSG00000140543
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	Q7L5Y6
PDB IDs		5HQG 5IGQ	9DHD
Enriched GO Terms of Interacting Partners?		Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Cell Population Proliferation Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Response To Antibiotic Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Phosphoserine Residue Binding Transcription Factor AP-1 Complex Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Repressor Complex Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Antibiotic Negative Regulation Of Protein Kinase Activity DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Kinase Activity Protein Kinase Binding General Transcription Initiation Factor Binding Protein-containing Complex Negative Regulation Of Neuroblast Proliferation Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Transcription Regulator Complex	Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Protein Catabolic Process UV-damage Excision Repair WD40-repeat Domain Binding Response To Radiation Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation By Virus Of Viral Protein Levels In Host Cell Protein Ubiquitination Spindle Assembly Involved In Female Meiosis Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Epigenetic Programming In The Zygotic Pronuclei Meiotic Spindle Assembly Base-excision Repair, AP Site Formation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Programmed Cell Death Involved In Cell Development Meiotic Spindle Organization Positive Regulation Of Gluconeogenesis Cullin Family Protein Binding Cul4-RING E3 Ubiquitin Ligase Complex Viral Release From Host Cell Positive Regulation Of Viral Genome Replication Macromolecule Catabolic Process Epigenetic Programming Of Gene Expression Biological Process Involved In Interaction With Symbiont Proteolysis Positive Regulation Of Glucose Metabolic Process Nucleotide-excision Repair Type I Interferon-mediated Signaling Pathway Regulation Of Gluconeogenesis Positive Regulation Of Viral Process Damaged DNA Binding Regulation Of Protein Metabolic Process Negative Regulation Of Reproductive Process Interferon-mediated Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Regulation Of Viral Genome Replication Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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