RFWD2 and DET1

Number of citations of the paper that reports this interaction (PMID 14739464)
99

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		RFWD2	DET1
Gene Name		ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	de-etiolated homolog 1 (Arabidopsis)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Centrosome Cytosol Focal Adhesion Nuclear Speck	Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		p53-Dependent G1 DNA Damage Response Autodegradation of the E3 ubiquitin ligase COP1 Stabilization of p53 Cell Cycle Checkpoints p53-Dependent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CCT4 DET1 ETS1 ETS2 JUN JUND PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ	2 interactors: DDB1 RFWD2
Entrez ID		64326	55070
HPRD ID		07455	13140
Ensembl ID		ENSG00000143207	ENSG00000140543
Uniprot IDs		Q05CT6 Q8NHY2	Q7L5Y6
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Response To Abiotic Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Transcription From RNA Polymerase II Promoter Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Mitochondrion Organization Cellular Response To Extracellular Stimulus Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Regulation Of Mitochondrion Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Wounding Regulation Of Cellular Component Organization Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Stimulus Mitochondrion Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Cellular Response To Starvation Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Organelle Organization RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Endoplasmic Reticulum Stress Negative Regulation Of Programmed Cell Death Response To Extracellular Stimulus	Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Mitotic Cell Cycle Response To Radiation Regulation Of Cell Cycle Process UV-damage Excision Repair Positive Regulation Of Viral Release From Host Cell Protein Ubiquitination Protein Modification By Small Protein Conjugation Histone H2A Monoubiquitination Histone H2A Ubiquitination Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Damage Removal Regulation Of Cell Cycle Histone Monoubiquitination Positive Regulation Of Viral Genome Replication Regulation Of Viral Release From Host Cell Response To Abiotic Stimulus Interaction With Symbiont Histone Ubiquitination Protein Monoubiquitination Cellular Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To UV Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Viral Genome Replication Positive Regulation Of Proteasomal Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Viral Process Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			3c collections endo exo gal1 histidine hydrolyzes hydrophilic individually library morf movable mutases nuclease nucleases orf phosphatases phosphoglycerate plasmids pools radiolabeled sepharose tag tagged tripartite undertook ydr051c yor283w zz
Tagcloud (Difference) ?			3c collections endo exo gal1 histidine hydrolyzes hydrophilic individually library morf movable mutases nuclease nucleases orf phosphatases phosphoglycerate plasmids pools radiolabeled sepharose tag tagged tripartite undertook ydr051c yor283w zz
Tagcloud (Intersection) ?