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RFWD2 and SFN
Number of citations of the paper that reports this interaction (PMID
21625211
)
10
Data Source:
BioGRID
(enzymatic study)
RFWD2
SFN
Gene Name
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
stratifin
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Focal Adhesion
Nuclear Speck
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Vesicle Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Activity
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Kinase Binding
Protein Domain Specific Binding
Phosphoprotein Binding
Biological Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Response To Ionizing Radiation
Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Release Of Cytochrome C From Mitochondria
Keratinocyte Development
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Epidermal Cell Division
Negative Regulation Of Keratinocyte Proliferation
Positive Regulation Of Cell Growth
Keratinization
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Epidermal Cell Differentiation
Positive Regulation Of Protein Export From Nucleus
Membrane Organization
Establishment Of Skin Barrier
Negative Regulation Of Protein Serine/threonine Kinase Activity
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
p53-Dependent G1 DNA Damage Response
Autodegradation of the E3 ubiquitin ligase COP1
Stabilization of p53
Cell Cycle Checkpoints
p53-Dependent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Activation of BAD and translocation to mitochondria
Programmed Cell Death
Translocation of GLUT4 to the plasma membrane
Activation of BH3-only proteins
Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions
14 interactors:
CCT4
DET1
ETS1
ETS2
JUN
JUND
PTPN1
RB1CC1
SFN
SIPA1
TP53
UBE2D1
UBE2D2
YWHAZ
49 interactors:
ABL1
BAD
BAX
BCR
CCAR1
CCDC102B
CCNH
CDC25B
CDK1
CHST1
EEF1A1
EGFR
EIF2S1
EIF4B
EXO1
FAM189A2
FAM53C
FAM9B
FOXO4
GPRIN2
HDAC5
HNRNPD
ING1
KCNK15
KCNK3
KCNK9
KIAA0408
LONRF1
MAGEA1
MAP3K5
MARK3
MDM4
MKRN3
MST1R
NR3C1
PLEKHF2
PLK4
RAB3IP
RFFL
RFWD2
SAMSN1
TBL3
TP53
TRIM25
TSC2
WDYHV1
YWHAG
ZC2HC1C
ZFP36
Entrez ID
64326
2810
HPRD ID
07455
03185
Ensembl ID
ENSG00000143207
ENSG00000175793
Uniprot IDs
Q05CT6
Q8NHY2
P31947
PDB IDs
1YWT
1YZ5
3IQJ
3IQU
3IQV
3LW1
3MHR
3O8I
3P1N
3P1O
3P1P
3P1Q
3P1R
3P1S
3SMK
3SML
3SMM
3SMN
3SMO
3SPR
3T0L
3T0M
3U9X
3UX0
4DAT
4DAU
4DHM
4DHN
4DHO
4DHP
4DHQ
4DHR
4DHS
4DHT
4DHU
4FR3
4HQW
4HRU
4IEA
4JC3
4JDD
Enriched GO Terms of Interacting Partners
?
Cellular Response To Stress
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Response To Abiotic Stimulus
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Stress
Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Transcription From RNA Polymerase II Promoter
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Mitochondrion Organization
Cellular Response To Extracellular Stimulus
Regulation Of Cell Cycle
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Apoptotic Mitochondrial Changes
Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Response To Hypoxia
Regulation Of Mitochondrion Organization
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Hypoxia
Intracellular Signal Transduction
Cellular Response To Decreased Oxygen Levels
Response To Wounding
Regulation Of Cellular Component Organization
Toll-like Receptor Signaling Pathway
Apoptotic Signaling Pathway
Cellular Response To Oxygen Levels
Cellular Response To Stimulus
Mitochondrion Organization
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Immune System Process
Cellular Response To Starvation
Transforming Growth Factor Beta Receptor Signaling Pathway
Activation Of Innate Immune Response
Regulation Of Apoptotic Process
Organelle Organization
RNA Metabolic Process
Transcription, DNA-templated
Negative Regulation Of Cell Cycle
Negative Regulation Of Apoptotic Process
Regulation Of Cell Death
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Programmed Cell Death
Response To Extracellular Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Neuron Death
Cell Cycle
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Cellular Response To Organic Substance
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Kinase Activity
Cellular Response To Organonitrogen Compound
Regulation Of Phosphorus Metabolic Process
Cell Cycle Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Intracellular Transport
Mitotic Cell Cycle Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Intracellular Signal Transduction
ERBB Signaling Pathway
Regulation Of Protein Kinase Activity
Response To Stress
Mitotic Cell Cycle
Positive Regulation Of Cell Cycle
Response To Organic Substance
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Cell Cycle
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stress
Cellular Response To DNA Damage Stimulus
Regulation Of Catalytic Activity
Cellular Response To Insulin Stimulus
G2/M Transition Of Mitotic Cell Cycle
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Mitotic Cell Cycle
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Mitochondrion Organization
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Hormone
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Regulation Of Intracellular Signal Transduction
Cellular Response To Hormone Stimulus
Regulation Of Cell Proliferation
B Cell Activation
Fc Receptor Signaling Pathway
Tagcloud
?
aging
alarm
amplitude
auditory
circuits
cortico
elderly
electrophysiologically
employed
false
finding
frontal
impairments
latency
limbic
memory
n4
p3
perform
position
potentials
prefrontal
recency
serial
sternberg
subjects
task
working
young
Tagcloud (Difference)
?
aging
alarm
amplitude
auditory
circuits
cortico
elderly
electrophysiologically
employed
false
finding
frontal
impairments
latency
limbic
memory
n4
p3
perform
position
potentials
prefrontal
recency
serial
sternberg
subjects
task
working
young
Tagcloud (Intersection)
?