COP1 and SIPA1

Number of citations of the paper that reports this interaction (PubMedID 11461903)
0

Data Source:
HPRD (two hybrid, in vitro)

		COP1	SIPA1
Description		COP1 E3 ubiquitin ligase	signal-induced proliferation-associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm Cytosol Endomembrane System Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	GTPase Activator Activity Protein Binding
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Adaptive Immune Response Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Negative Regulation Of Cell Growth Intracellular Signal Transduction Cellular Response To Water Deprivation Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation	Rap1 signalling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	A body shape index ( 34021172) Acne (severe) ( 24927181) Asthma ( 31619474) Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) HDL cholesterol ( 30275531) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet count ( 27863252) Pulse pressure ( 30578418) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27618452 30578418 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: CDKN1B CUL4B DET1 ETS1 ETS2 GATA2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ	4 interacting genes: CDKN1A COP1 DVL1 SHANK3
Entrez ID		64326	6494
HPRD ID		07455	03713
Ensembl ID		ENSG00000143207	ENSG00000213445
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	Q96FS4
PDB IDs		5HQG 5IGQ
Enriched GO Terms of Interacting Partners?		Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Cell Population Proliferation Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Response To Antibiotic Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Phosphoserine Residue Binding Transcription Factor AP-1 Complex Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Repressor Complex Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Antibiotic Negative Regulation Of Protein Kinase Activity DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Kinase Activity Protein Kinase Binding General Transcription Initiation Factor Binding Protein-containing Complex Negative Regulation Of Neuroblast Proliferation Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Transcription Regulator Complex	Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Receptor Clustering Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Social Behavior Dendritic Spine Organization Postsynapse Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Response To Ionizing Radiation Positive Regulation Of Protein Localization To Presynapse Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Postsynapse Organization Regulation Of Nervous System Process Dendritic Spine Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Guanylate Kinase-associated Protein Clustering Protein Localization To Nucleus Convergent Extension Involved In Neural Plate Elongation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Catabolic Process Synaptic Receptor Adaptor Activity Convergent Extension Involved In Organogenesis Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Postsynaptic Density Synapse Organization Neuron Projection Morphogenesis Convergent Extension Involved In Gastrulation Positive Regulation Of Protein Localization To Synapse Oncogene-induced Cell Senescence Stress-induced Premature Senescence Cell Projection Morphogenesis Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Positive Regulation Of Neuron Projection Arborization Regulation Of Synapse Organization Protein Localization To Membrane Vocal Learning
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