RFWD2 and PTPN1

Number of citations of the paper that reports this interaction (PMID 23439647)
1

Data Source:
BioGRID (pull down)

		RFWD2	PTPN1
Gene Name		ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	protein tyrosine phosphatase, non-receptor type 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Centrosome Cytosol Focal Adhesion Nuclear Speck	Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cytoplasmic Vesicle Sorting Endosome
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Poly(A) RNA Binding Ephrin Receptor Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Blood Coagulation Insulin Receptor Signaling Pathway Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Endocytosis Platelet Activation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Actin Cytoskeleton Reorganization Peptidyl-tyrosine Dephosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		p53-Dependent G1 DNA Damage Response Autodegradation of the E3 ubiquitin ligase COP1 Stabilization of p53 Cell Cycle Checkpoints p53-Dependent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints	Interferon gamma signaling Regulation of IFNA signaling Interferon Signaling Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Regulation of IFNG signaling Growth hormone receptor signaling
Drugs			Tiludronate 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid Double Oxidized Cysteine Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-Napthylalaniamide Compound 9 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid, 2-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic Acid Compound 19 Sp7343-Sp7964 2-(Oxalyl-Amino)-Benzoic Acid {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid) Novo Nordisk a/S Compound N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic Acid 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid PNU177836 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide 4-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric Acid N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic Acid Cysteinesulfonic Acid 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester) 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid 2-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic Acid 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID 3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE 3(R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID ISOTHIAZOLIDINONE ANALOG 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid PARA-(BENZOYL)-PHENYLALANINE 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CCT4 DET1 ETS1 ETS2 JUN JUND PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ	44 interactors: ACTN1 AKT1 ASS1 BCAR1 BCR CAPN2 CAV1 CDH2 CDK1 CLK1 CLK2 CRK CSNK2A1 CSNK2A2 CTNNB1 EGFR ESR1 GHR GLRX GRB2 GSK3B IGF1R INSR IRS1 JAK2 LAT LTK MAPK1 NFKBIA NTRK1 NTRK2 NTRK3 PDGFRB PIAS1 PIN1 RFWD2 RRAS2 SRC STAM2 STAT3 STAT5A STAT5B TRPV6 TYK2
Entrez ID		64326	5770
HPRD ID		07455	01477
Ensembl ID		ENSG00000143207	ENSG00000196396
Uniprot IDs		Q05CT6 Q8NHY2	A8K3M3 B4DSN5 P18031
PDB IDs			1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3A5J 3A5K 3CWE 3D9C 3EAX 3EB1 3EU0 3I7Z 3I80 3QKP 3QKQ 3SME 3ZV2 4I8N
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Response To Abiotic Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Transcription From RNA Polymerase II Promoter Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Mitochondrion Organization Cellular Response To Extracellular Stimulus Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Regulation Of Mitochondrion Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Wounding Regulation Of Cellular Component Organization Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Stimulus Mitochondrion Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Cellular Response To Starvation Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Organelle Organization RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Endoplasmic Reticulum Stress Negative Regulation Of Programmed Cell Death Response To Extracellular Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of MAPK Cascade Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Hormone Peptidyl-amino Acid Modification Cellular Response To Hormone Stimulus Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Response To Peptide Response To Organonitrogen Compound Intracellular Signal Transduction Response To Growth Factor Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Response To Peptide Hormone Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Signaling Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Cell Proliferation Protein Phosphorylation Regulation Of Cellular Component Movement Regulation Of Cell Death Regulation Of Immune Response Signaling Phosphorylation Cellular Response To Stimulus Positive Regulation Of MAPK Cascade Cell Communication Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Immune System Process Regulation Of Phosphorylation Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Defense Response Regulation Of Intracellular Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?			12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses rca1 xpq xq25
Tagcloud (Difference) ?			12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses rca1 xpq xq25
Tagcloud (Intersection) ?