COP1 and ETS2

Number of citations of the paper that reports this interaction (PubMedID 25117710)
56

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		COP1	ETS2
Description		COP1 E3 ubiquitin ligase	ETS proto-oncogene 2, transcription factor
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation	Oncogene Induced Senescence
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) Central corneal thickness ( 32528159) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) TPE interval (response to exercise) ( 32386560)
Interacting Genes		17 interacting genes: CDKN1B CUL4B DET1 ETS1 ETS2 GATA2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ	37 interacting genes: CDK10 CLU COP1 CREBBP DAD1 DMXL2 EGLN2 EP300 ERG ETS1 FOCAD FOS GABRD GATA3 GTF3C4 JUN NCOR1 NDRG1 NDUFB5 NR3C1 POU5F1 PPME1 RPL15 SERPINE2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 TERF2IP TTC3 UBC USP7 ZBTB44 ZFYVE9 ZMYND11
Entrez ID		64326	2114
HPRD ID		07455	01263
Ensembl ID		ENSG00000143207	ENSG00000157557
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	P15036
PDB IDs		5HQG 5IGQ	4BQA 4MHV
Enriched GO Terms of Interacting Partners?		Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Cell Population Proliferation Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Response To Antibiotic Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Phosphoserine Residue Binding Transcription Factor AP-1 Complex Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Repressor Complex Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Antibiotic Negative Regulation Of Protein Kinase Activity DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Kinase Activity Protein Kinase Binding General Transcription Initiation Factor Binding Protein-containing Complex Negative Regulation Of Neuroblast Proliferation Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Transcription Regulator Complex	Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Chromatin Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding DNA Binding Myeloid Cell Differentiation Chromatin Organization Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K27 Acetyltransferase Activity Positive Regulation Of Leukocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Pro-T Cell Differentiation Mononuclear Cell Differentiation Host-mediated Activation Of Viral Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Activation Response To Stress Myeloid Leukocyte Activation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell-cell Adhesion DNA-binding Transcription Factor Activity Transcription Regulator Complex Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Leukocyte Differentiation
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