Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
RFWD2 and ETS2
Number of citations of the paper that reports this interaction (PMID
25117710
)
0
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
RFWD2
ETS2
Gene Name
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
v-ets avian erythroblastosis virus E26 oncogene homolog 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Focal Adhesion
Nuclear Speck
Nucleus
Nucleoplasm
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Glucocorticoid Receptor Binding
Biological Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Response To Ionizing Radiation
Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Skeletal System Development
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
p53-Dependent G1 DNA Damage Response
Autodegradation of the E3 ubiquitin ligase COP1
Stabilization of p53
Cell Cycle Checkpoints
p53-Dependent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Cellular Senescence
Oncogene Induced Senescence
Drugs
Diseases
GWAS
Non-small cell lung cancer (
21079520
)
Protein-Protein Interactions
14 interactors:
CCT4
DET1
ETS1
ETS2
JUN
JUND
PTPN1
RB1CC1
SFN
SIPA1
TP53
UBE2D1
UBE2D2
YWHAZ
20 interactors:
CDK10
CREBBP
EP300
ERG
ETS1
FOS
GATA3
JUN
NCOR1
NR3C1
POU5F1
RFWD2
SMARCA4
SPI1
SRA1
SRC
STAT5B
TDP2
ZFYVE9
ZMYND11
Entrez ID
64326
2114
HPRD ID
07455
01263
Ensembl ID
ENSG00000143207
ENSG00000157557
Uniprot IDs
Q05CT6
Q8NHY2
P15036
PDB IDs
4BQA
4MHV
Enriched GO Terms of Interacting Partners
?
Cellular Response To Stress
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Response To Abiotic Stimulus
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Stress
Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Transcription From RNA Polymerase II Promoter
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Mitochondrion Organization
Cellular Response To Extracellular Stimulus
Regulation Of Cell Cycle
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Apoptotic Mitochondrial Changes
Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Response To Hypoxia
Regulation Of Mitochondrion Organization
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Hypoxia
Intracellular Signal Transduction
Cellular Response To Decreased Oxygen Levels
Response To Wounding
Regulation Of Cellular Component Organization
Toll-like Receptor Signaling Pathway
Apoptotic Signaling Pathway
Cellular Response To Oxygen Levels
Cellular Response To Stimulus
Mitochondrion Organization
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Immune System Process
Cellular Response To Starvation
Transforming Growth Factor Beta Receptor Signaling Pathway
Activation Of Innate Immune Response
Regulation Of Apoptotic Process
Organelle Organization
RNA Metabolic Process
Transcription, DNA-templated
Negative Regulation Of Cell Cycle
Negative Regulation Of Apoptotic Process
Regulation Of Cell Death
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Programmed Cell Death
Response To Extracellular Stimulus
Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Cell Cycle
Regulation Of Signal Transduction
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Myeloid Cell Differentiation
Positive Regulation By Host Of Viral Transcription
Response To Steroid Hormone
Response To Abiotic Stimulus
Negative Regulation Of Transcription, DNA-templated
Regulation Of Signaling
Gland Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Nitrogen Compound Metabolic Process
Response To Lipid
Biosynthetic Process
Leukocyte Differentiation
Immune System Process
Cellular Response To Growth Factor Stimulus
Regulation Of Myeloid Cell Differentiation
Response To Organic Cyclic Compound
Tissue Development
Tagcloud
?
3t3
activates
ap
blocked
colony
confirming
constitutive
cotransfected
cotransfection
dominant
downstream
erbb
families
focus
mutants
neu
neut
nih
oncogenic
parallel
points
raf
ras
reporter
residue
threonine
transforming
transmembrane
Tagcloud (Difference)
?
3t3
activates
ap
blocked
colony
confirming
constitutive
cotransfected
cotransfection
dominant
downstream
erbb
families
focus
mutants
neu
neut
nih
oncogenic
parallel
points
raf
ras
reporter
residue
threonine
transforming
transmembrane
Tagcloud (Intersection)
?