JOSD1 and KRTAP10-4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		JOSD1	KRTAP10-4
Description		Josephin domain containing 1	keratin associated protein 10-4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Hydrolase Activity Deubiquitinase Activity	Protein Binding
	Biological Process	Proteolysis Endocytosis Protein Deubiquitination Membrane Biogenesis Cell Motility Membrane Organization
Pathways		Josephin domain DUBs	Keratinization
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plateletcrit ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Leukocyte telomere length ( 32109421)
Interacting Genes		38 interacting genes: ADAMTSL4 CARD10 CYSRT1 FBLN2 KRT27 KRT31 KRT34 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PJA1 STUB1 TGM1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 UBC USP15 USP21 USP28	11 interacting genes: CATSPER1 E4F1 HOXA1 IGSF8 JOSD1 OTX1 RSPO2 WT1 ZNF32 ZNF625 ZSCAN26
Entrez ID		9929	386672
HPRD ID		08823	11190
Ensembl ID		ENSG00000100221	ENSG00000215454
Uniprot IDs		Q15040	P60372
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Identical Protein Binding Intermediate Filament Organization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Protein Modification Process Ubiquitin-protein Transferase Activity Epidermis Development Negative Regulation Of Viral Transcription Positive Regulation Of Autophagy Suppression Of Viral Release By Host Structural Molecule Activity Supramolecular Fiber Organization Regulation Of Viral Transcription Microtubule Cysteine-type Deubiquitinase Activity Protein Deubiquitination Deubiquitinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Tube Morphogenesis Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Abducens Nerve Formation Optokinetic Behavior Diencephalon Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Regulation Of Animal Organ Morphogenesis Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Lung Growth Regulation Of RNA Metabolic Process Metencephalon Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Trachea Cartilage Morphogenesis Embryonic Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Branching Morphogenesis Of An Epithelial Tube Double-stranded Methylated DNA Binding S-shaped Body Morphogenesis Zinc Ion Binding Embryonic Neurocranium Morphogenesis Anterior/posterior Pattern Specification Diaphragm Development Regulation Of Female Gonad Development Morphogenesis Of A Branching Structure Positive Regulation Of Male Gonad Development Morphogenesis Of A Branching Epithelium Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Membrane Biogenesis CatSper Complex Outer Ear Morphogenesis
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