ATXN3L and RFFL

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		ATXN3L	RFFL
Gene Name		ataxin 3-like	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix Mitochondrial Membrane Nuclear Inclusion Body	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Recycling Endosome Membrane
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding Histone Deacetylase Activity Ubiquitin-specific Protease Activity Omega Peptidase Activity Ubiquitin Protein Ligase Binding	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Misfolded Or Incompletely Synthesized Protein Catabolic Process Protein Deubiquitination Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H3 Deacetylation Cellular Response To Misfolded Protein	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways
Drugs
Diseases
GWAS			QT interval ( 19305408)
Protein-Protein Interactions		6 interactors: PJA1 RFFL TRIM54 TRIM55 TRIM63 USP28	15 interactors: ATXN3 ATXN3L ESPL1 OTUB1 OTUB2 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UCHL5 USP28 USP5 USP7
Entrez ID		92552	117584
HPRD ID		19697	11489
Ensembl ID		ENSG00000123594	ENSG00000092871
Uniprot IDs		B4DYC7 Q9H3M9	Q8WZ73
PDB IDs		3O65	1Y02
Enriched GO Terms of Interacting Partners?		Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Cellular Macromolecule Catabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Negative Regulation Of Execution Phase Of Apoptosis Skeletal Muscle Adaptation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Protein Modification Process Proteolysis Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Response To Dexamethasone Stimulus Regulation Of Fibroblast Migration Response To Dexamethasone Negative Regulation Of Microtubule Depolymerization Protein K48-linked Ubiquitination Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Proteolysis Response To Electrical Stimulus Regulation Of Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Microtubule Polymerization Or Depolymerization Cellular Protein Metabolic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Cellular Response To UV	Protein Deubiquitination Protein Modification By Small Protein Removal Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K48-linked Ubiquitination Cellular Protein Modification Process Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia DNA Repair Protein Polyubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Monoubiquitinated Protein Deubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization DNA Metabolic Process Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Misfolded Protein Protein K63-linked Deubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of Innate Immune Response
Tagcloud ?			biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency select span stressors throughput tiam1 transmit uncharacterized
Tagcloud (Difference) ?			biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency select span stressors throughput tiam1 transmit uncharacterized
Tagcloud (Intersection) ?