ZNF440 and MAP4K5

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		ZNF440	MAP4K5
Gene Name		zinc finger protein 440	mitogen-activated protein kinase kinase kinase kinase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Protein Phosphorylation Activation Of JUN Kinase Activity Intracellular Signal Transduction
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS			Cognitive performance ( 20125193)
Protein-Protein Interactions		12 interactors: KRTAP10-1 KRTAP10-9 KRTAP4-12 MAP4K5 MDFI MID2 MTUS2 NOTCH2NL PAX9 PJA1 TRAF1 XBP1	12 interactors: ABL1 BCR COPS5 CRK CRKL GRB2 HCK NEDD4 SETDB1 TANK TRAF2 ZNF440
Entrez ID		126070	11183
HPRD ID		11718	05374
Ensembl ID		ENSG00000171295	ENSG00000012983
Uniprot IDs		Q8IYI8	B3KWC4 Q9Y4K4
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Negative Regulation Of RNA Biosynthetic Process Regulation Of JUN Kinase Activity JNK Cascade Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Kinase Activity Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress-activated MAPK Cascade Positive Regulation Of Transferase Activity Stress-activated Protein Kinase Signaling Cascade Cell Differentiation Involved In Salivary Gland Development Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Signal Transduction Activation Of MAPK Activity Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of JNK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Protein Phosphorylation Regulation Of Protein Import Into Nucleus Regulation Of Protein Kinase Activity Regulation Of Signaling Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Serotonin Secretion Regulation Of Intracellular Signal Transduction Regulation Of Organ Morphogenesis Regulation Of Stress-activated MAPK Cascade Regulation Of Kinase Activity Regulation Of Protein Localization To Nucleus Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Hepatocyte Proliferation Cellular Response To Fructose Stimulus Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Phosphorylation MAPK Cascade Cellular Response To Laminar Fluid Shear Stress	Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Innate Immune Response Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Response To Organic Substance Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Endocytosis Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Defense Response Regulation Of Actin Cytoskeleton Organization Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Regulation Of Actin Filament-based Process Regulation Of Phosphorus Metabolic Process Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Response To Stress Cellular Response To Organonitrogen Compound Regulation Of Cytoskeleton Organization Positive Regulation Of Innate Immune Response Regulation Of Endocytosis Protein K63-linked Ubiquitination Intracellular Signal Transduction Signal Transduction Positive Regulation Of Interleukin-2 Production Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway
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