AP1M1 and ZNF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AP1M1	ZNF8
Description		adaptor related protein complex 1 subunit mu 1	zinc finger protein 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome	Nucleus
	Molecular Function	Protein Binding Clathrin Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription BMP Signaling Pathway
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668)
Interacting Genes		103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16	8 interacting genes: AP1M1 MCRS1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 ZNF114
Entrez ID		8907	7554
HPRD ID		04639	01919
Ensembl ID		ENSG00000072958	ENSG00000278129
Uniprot IDs		B3KNH5 Q59EK3 Q9BXS5	B3KS94 P17098
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process	SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Embryonic Pattern Specification Transforming Growth Factor Beta Receptor Signaling Pathway Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development DEAD/H-box RNA Helicase Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Tube Development Kidney Epithelium Development Transcription Regulator Complex Cardiac Conduction System Development Response To Growth Factor Homomeric SMAD Protein Complex R-SMAD Binding Osteoblast Differentiation Activin Receptor Signaling Pathway Pattern Specification Process Endoderm Development MiRNA Processing Osteoblast Fate Commitment Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Cell Fate Commitment RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Gastrulation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anti-Mullerian Hormone Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription Mesoderm Morphogenesis Epithelium Development Positive Regulation Of Epithelial To Mesenchymal Transition Cardiac Muscle Tissue Development Positive Regulation Of MiRNA Metabolic Process Pericardium Development Intracellular Iron Ion Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Enzyme-linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta Trophoblast Cell Migration DNA-binding Transcription Factor Activity Cellular Response To Growth Factor Stimulus Regulation Of MiRNA Transcription Regulation Of Transforming Growth Factor Beta2 Production
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