AP1M1 and PIGR

Number of citations of the paper that reports this interaction (PMID 10809756)
23

Data Source:
HPRD (in vivo)

		AP1M1	PIGR
Gene Name		adaptor-related protein complex 1, mu 1 subunit	polymeric immunoglobulin receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Membrane Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Extracellular Vesicular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Polymeric Immunoglobulin Receptor Activity
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Regulation Of Defense Response To Virus By Virus Membrane Organization	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Retina Homeostasis Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		43 interactors: AP1B1 AP1M2 AP2B1 BRCA1 CEP57L1 CORO7 CTLA4 DCX DVL2 DZIP3 EHD2 ETV6 FAM9B FXR2 GAK GRIN2A GRIN2B HNRNPC HOOK2 IKZF1 KIF13A KRT40 KRTAP10-3 KRTAP10-7 LAMP1 LDOC1 LZTS2 MTF1 PHC2 PIGR PNMA5 RUNDC3A SDCCAG3 SELP SSX2IP TGOLN2 TIFA TNIP1 VAMP4 ZBTB14 ZBTB43 ZBTB44 ZBTB8A	4 interactors: AP1M1 CCL5 CD79A RAB3B
Entrez ID		8907	5284
HPRD ID		04639	01436
Ensembl ID		ENSG00000072958	ENSG00000162896
Uniprot IDs		B3KNH5 E7ENJ6 Q59EK3 Q9BXS5	P01833
PDB IDs			1XED 2OCW 3CHN 3CM9
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cellular Localization Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Defense Response To Virus By Virus Intracellular Transport Endosomal Transport Protein Localization Lysosomal Transport Golgi Vesicle Transport Regulation Of Immune System Process Cellular Protein Localization Vacuolar Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Microtubule Cytoskeleton Organization Endomembrane System Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Transport Regulation Of Cellular Process Startle Response Microtubule-based Process Endosome To Lysosome Transport Positive Regulation Of Cell Activation Cytoskeleton Organization Clathrin-mediated Endocytosis Establishment Of Protein Localization Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Histone H4-K20 Methylation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Histone H4-K16 Acetylation Membrane Organization Cellular Protein Complex Assembly Organelle Organization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Intrahepatic Bile Duct Development Positive Regulation Of Natural Killer Cell Degranulation Selenium Compound Metabolic Process Cytoplasmic Transport Glutamate Receptor Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Golgi To Lysosome Transport Neuron-neuron Synaptic Transmission	Immune System Process Regulation Of Vesicle Size Positive Regulation Of Ion Transport Peptidyl-cysteine Methylation Negative Regulation Of Macrophage Apoptotic Process Regulation Of Immune System Process Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Antigen Processing And Presentation Vesicle-mediated Transport Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Activation Of Janus Kinase Activity Exocytosis Positive Regulation Of Macrophage Chemotaxis Pigment Granule Maturation Endosome To Melanosome Transport Eosinophil Chemotaxis Eosinophil Migration Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of T Cell Chemotaxis Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Pigment Accumulation Negative Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Establishment Of Localization In Cell Regulation Of Macrophage Chemotaxis Regulation Of Monocyte Chemotaxis Positive Regulation Of Translational Initiation Dendritic Cell Chemotaxis Leukocyte Activation Activation Of Phospholipase D Activity Regulation Of Neurotransmitter Uptake Positive Regulation Of T Cell Apoptotic Process Monocyte Chemotaxis Regulation Of Macrophage Apoptotic Process Secretion By Cell Positive Regulation Of Cell Adhesion Mediated By Integrin Macrophage Chemotaxis Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of T Cell Migration Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process Regulation Of T Cell Migration Negative Regulation Of Viral Transcription Melanosome Organization
Tagcloud ?		19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic	adenoids belonging defense degranulation destructive dimers eosinophils extravasation glandular helper iga ige immunopathology leukocytes migrate mucosa penetrating perhaps piga polymers priming reaches secretions secretory th2 tonsils transported unsuccessful
Tagcloud (Difference) ?		19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic	adenoids belonging defense degranulation destructive dimers eosinophils extravasation glandular helper iga ige immunopathology leukocytes migrate mucosa penetrating perhaps piga polymers priming reaches secretions secretory th2 tonsils transported unsuccessful
Tagcloud (Intersection) ?