AP1M1 and NKAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AP1M1	NKAP
Description		adaptor related protein complex 1 subunit mu 1	NFKB activating protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Chromatin Binding RNA Binding Protein Binding Chromatin DNA Binding
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Hemopoiesis Granulocyte Differentiation T Cell Differentiation In Thymus Somatic Stem Cell Population Maintenance Negative Regulation Of DNA-templated Transcription Positive Regulation Of Alpha-beta T Cell Differentiation Hematopoietic Stem Cell Proliferation
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668)
Interacting Genes		103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16	17 interacting genes: AP1M1 CEP70 DHX15 FAM124A FRA10AC1 LUC7L2 OGT PCBP2 PRPF3 PRPF40A RBM39 RBMX2 SRPK1 SRPK2 THAP1 TTC14 U2AF1
Entrez ID		8907	79576
HPRD ID		04639	06666
Ensembl ID		ENSG00000072958	ENSG00000101882
Uniprot IDs		B3KNH5 Q59EK3 Q9BXS5	Q8N5F7
PDB IDs			6QDV 7W5B 8C6J 9FMD
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process	RNA Splicing MRNA Metabolic Process MRNA Processing Nuclear Speck RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions RNA Binding Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Spliceosomal Complex Assembly RS Domain Binding Spliceosomal Complex Nucleoplasm U2-type Prespliceosome U1 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Macromolecule Metabolic Process Positive Regulation Of Viral Genome Replication Regulation Of RNA Splicing Protein-containing Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleus Negative Regulation Of Viral Genome Replication Cellular Component Assembly U2-type Precatalytic Spliceosome Positive Regulation Of Viral Process Protein-containing Complex Organization Cajal Body Negative Regulation Of Viral Process Regulation Of Viral Genome Replication U2-type Post-mRNA Release Spliceosomal Complex Protein O-acetylglucosaminyltransferase Activity Innate Immune Response Regulation Of MRNA Metabolic Process Nuclear Speck Organization
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