AP1M1 and GAK

Number of citations of the paper that reports this interaction (PMID 10887964)
42

Data Source:
HPRD (in vitro)

		AP1M1	GAK
Gene Name		adaptor-related protein complex 1, mu 1 subunit	cyclin G associated kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Membrane Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Extracellular Vesicular Exosome	Golgi Apparatus Focal Adhesion Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Regulation Of Defense Response To Virus By Virus Membrane Organization	Protein Phosphorylation Endoplasmic Reticulum Organization Golgi Organization Cell Cycle Epidermal Cell Differentiation Intrahepatic Bile Duct Development Cell Development Forebrain Morphogenesis Establishment Of Skin Barrier Clathrin Coat Disassembly Clathrin-mediated Endocytosis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Parkinson's disease ( 20711177 21292315 22438815 21738487) Parkinson's disease (familial) ( 18985386)
Protein-Protein Interactions		43 interactors: AP1B1 AP1M2 AP2B1 BRCA1 CEP57L1 CORO7 CTLA4 DCX DVL2 DZIP3 EHD2 ETV6 FAM9B FXR2 GAK GRIN2A GRIN2B HNRNPC HOOK2 IKZF1 KIF13A KRT40 KRTAP10-3 KRTAP10-7 LAMP1 LDOC1 LZTS2 MTF1 PHC2 PIGR PNMA5 RUNDC3A SDCCAG3 SELP SSX2IP TGOLN2 TIFA TNIP1 VAMP4 ZBTB14 ZBTB43 ZBTB44 ZBTB8A	12 interactors: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 USO1
Entrez ID		8907	2580
HPRD ID		04639	03631
Ensembl ID		ENSG00000072958	ENSG00000178950
Uniprot IDs		B3KNH5 E7ENJ6 Q59EK3 Q9BXS5	E9PGR2 O14976
PDB IDs			3LL6
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cellular Localization Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Defense Response To Virus By Virus Intracellular Transport Endosomal Transport Protein Localization Lysosomal Transport Golgi Vesicle Transport Regulation Of Immune System Process Cellular Protein Localization Vacuolar Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Microtubule Cytoskeleton Organization Endomembrane System Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Transport Regulation Of Cellular Process Startle Response Microtubule-based Process Endosome To Lysosome Transport Positive Regulation Of Cell Activation Cytoskeleton Organization Clathrin-mediated Endocytosis Establishment Of Protein Localization Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Histone H4-K20 Methylation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Histone H4-K16 Acetylation Membrane Organization Cellular Protein Complex Assembly Organelle Organization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Intrahepatic Bile Duct Development Positive Regulation Of Natural Killer Cell Degranulation Selenium Compound Metabolic Process Cytoplasmic Transport Glutamate Receptor Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Golgi To Lysosome Transport Neuron-neuron Synaptic Transmission	Intracellular Transport Establishment Of Localization In Cell Membrane Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Golgi Vesicle Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Localization Regulation Of Defense Response To Virus By Virus Cell Growth Intracellular Protein Transport Regulation Of Protein Localization To Plasma Membrane Antigen Processing And Presentation Of Peptide Antigen Viral Process Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Developmental Process Cellular Protein Localization Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization Protein Transport Axon Guidance Establishment Of Protein Localization Negative Regulation Of Protein Localization To Plasma Membrane Cell Differentiation Anatomical Structure Morphogenesis Growth Regulation Of Cellular Localization Regulation Of Cellular Response To Heat Axonogenesis Cell Development Axon Development Neuron Differentiation Protein Localization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Endocytosis Regulation Of Phosphorylation Cytoplasmic Transport Organelle Organization Immune System Process Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Neuron Apoptotic Process Brain Development
Tagcloud ?		19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic	atp13a2 bst1 conclusively confirmation discuss dj1 eif4g1 familial fbxo7 gba gigyf2 growing hla hopefully htra2 loci lrrk2 mapt park16 parkin parkinson parkinsonism pink1 pla2g6 rare respective snca sporadic uchl1
Tagcloud (Difference) ?		19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic	atp13a2 bst1 conclusively confirmation discuss dj1 eif4g1 familial fbxo7 gba gigyf2 growing hla hopefully htra2 loci lrrk2 mapt park16 parkin parkinson parkinsonism pink1 pla2g6 rare respective snca sporadic uchl1
Tagcloud (Intersection) ?