AP1M1 and GAK

Number of citations of the paper that reports this interaction (PubMedID 10887964)
0

Data Source:
HPRD (in vitro)

		AP1M1	GAK
Description		adaptor related protein complex 1 subunit mu 1	cyclin G associated kinase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Anchoring Junction Presynapse
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Clathrin Binding Cyclin Binding Protein Folding Chaperone Protein Serine Kinase Activity
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly	Protein Folding Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Intracellular Transport Clathrin Coat Assembly Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Regulation Of Clathrin Coat Assembly
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs			Fostamatinib
Diseases
GWAS		Coronary artery disease ( 33020668)	A body shape index ( 34021172) HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 32310270 27182965 25064009 22438815 21738487 21292315) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16	14 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1
Entrez ID		8907	2580
HPRD ID		04639	03631
Ensembl ID		ENSG00000072958	ENSG00000178950
Uniprot IDs		B3KNH5 Q59EK3 Q9BXS5	B4DS37 O14976
PDB IDs			4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process	Intracellular Transport Intracellular Protein Transport Clathrin Adaptor Complex Regulation Of Protein Localization Clathrin Adaptor Activity Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization Cellular Localization Establishment Of Localization In Cell Low-density Lipoprotein Particle Receptor Binding Regulation Of Protein Import Trans-Golgi Network Membrane Regulation Of Protein Localization To Plasma Membrane Cytoplasmic Vesicle Clathrin Coat Disassembly Regulation Of Protein Localization To Cell Periphery Vesicle Uncoating Regulation Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Clathrin-coated Pit P53 Binding Clathrin-coated Vesicle Establishment Of Protein Localization AP-1 Adaptor Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Endolysosome Membrane Transcytosis Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine/threonine Kinase Binding Clathrin-coated Endocytic Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Disordered Domain Specific Binding Regulation Of JNK Cascade Regulation Of Proteolysis Negative Regulation Of Biosynthetic Process Positive Regulation Of Receptor Internalization Lysosomal Membrane Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein Localization To Plasma Membrane Enzyme Binding Regulation Of Protein Localization To Nucleus Clathrin-dependent Endocytosis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Component Assembly
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