AP1M1 and LAMP1

Number of citations: 0 (PubMedID 7569928)
Data Source: HPRD (two hybrid, in vitro)

		AP1M1	LAMP1
Name		adaptor related protein complex 1 subunit mu 1	lysosomal associated membrane protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Sarcolemma Melanosome Cytolytic Granule Autolysosome Phagocytic Vesicle Perinuclear Region Of Cytoplasm Phagolysosome Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane Cytolytic Granule Membrane
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Virus Receptor Activity Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly	Lysosomal Lumen Acidification Lysosomal Lumen PH Elevation Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Protein Stabilization Establishment Of Protein Localization To Organelle Golgi To Lysosome Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Regulation Of Organelle Transport Along Microtubule Proton Transmembrane Transport
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	Neutrophil degranulation
GWAS		Coronary artery disease ( 33020668 )	Bipolar disorder ( 31043756 )
Interacting Genes		103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16	4 interacting genes: AP1M1 AP2M1 SLC48A1 VSTM1
Entrez ID		8907	3916
HPRD ID		04639	01076
Ensembl ID		ENSG00000072958	ENSG00000185896
Uniprot IDs		B3KNH5 Q59EK3 Q9BXS5	B3KRY3 P11279
PDB IDs		Not available	8ATH 8FY5 8FYF 9C59 9C5A 9C5B
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process	Clathrin Adaptor Complex Clathrin Adaptor Activity Lysosomal Membrane Heme Export From Vacuole To Cytoplasm Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Cytoplasmic Vesicle Plasma Membrane Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Endolysosome Heme Transmembrane Transport Heme Transmembrane Transporter Activity Localization Of Cell Heme Export Heme Transport Phagolysosome Membrane Vacuolar Transmembrane Transport Vesicle-mediated Transport Intracellular Transport Positive Regulation Of Fatty Acid Beta-oxidation Cellular Response To Endothelin Endosome To Melanosome Transport Vesicle Organization AP-2 Adaptor Complex Response To Endothelin Regulation Of Type B Pancreatic Cell Proliferation AP-1 Adaptor Complex Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Fatty Acid Oxidation Regulation Of Vesicle Size Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Melanosome Assembly Iron Ion Transmembrane Transport Endolysosome Membrane Regulation Of B Cell Apoptotic Process Cellular Localization Endocytosis Establishment Of Localization In Cell Clathrin-coated Endocytic Vesicle