AP1M1 and LAMP1

Number of citations of the paper that reports this interaction (PMID 7569928)
266

Data Source:
HPRD (in vitro, two hybrid)

		AP1M1	LAMP1
Gene Name		adaptor-related protein complex 1, mu 1 subunit	lysosomal-associated membrane protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Membrane Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Extracellular Vesicular Exosome	Cytoplasm Lysosome Late Endosome Multivesicular Body Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Dendrite Sarcolemma Melanosome Neuronal Cell Body Cytolytic Granule Phagolysosome Membrane Extracellular Vesicular Exosome Alveolar Lamellar Body
	Molecular Function	Protein Binding	Protein Binding Enzyme Binding Protein Domain Specific Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Regulation Of Defense Response To Virus By Virus Membrane Organization	Autophagy Granzyme-mediated Apoptotic Signaling Pathway Viral Process Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Autophagic Cell Death Protein Stabilization Establishment Of Protein Localization To Organelle Golgi To Lysosome Transport Regulation Of Organelle Transport Along Microtubule
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: AP1B1 AP1M2 AP2B1 BRCA1 CEP57L1 CORO7 CTLA4 DCX DVL2 DZIP3 EHD2 ETV6 FAM9B FXR2 GAK GRIN2A GRIN2B HNRNPC HOOK2 IKZF1 KIF13A KRT40 KRTAP10-3 KRTAP10-7 LAMP1 LDOC1 LZTS2 MTF1 PHC2 PIGR PNMA5 RUNDC3A SDCCAG3 SELP SSX2IP TGOLN2 TIFA TNIP1 VAMP4 ZBTB14 ZBTB43 ZBTB44 ZBTB8A	2 interactors: AP1M1 AP2M1
Entrez ID		8907	3916
HPRD ID		04639	01076
Ensembl ID		ENSG00000072958	ENSG00000185896
Uniprot IDs		B3KNH5 E7ENJ6 Q59EK3 Q9BXS5	B4DWL3 P11279
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cellular Localization Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Defense Response To Virus By Virus Intracellular Transport Endosomal Transport Protein Localization Lysosomal Transport Golgi Vesicle Transport Regulation Of Immune System Process Cellular Protein Localization Vacuolar Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Microtubule Cytoskeleton Organization Endomembrane System Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Transport Regulation Of Cellular Process Startle Response Microtubule-based Process Endosome To Lysosome Transport Positive Regulation Of Cell Activation Cytoskeleton Organization Clathrin-mediated Endocytosis Establishment Of Protein Localization Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Histone H4-K20 Methylation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Histone H4-K16 Acetylation Membrane Organization Cellular Protein Complex Assembly Organelle Organization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Intrahepatic Bile Duct Development Positive Regulation Of Natural Killer Cell Degranulation Selenium Compound Metabolic Process Cytoplasmic Transport Glutamate Receptor Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Golgi To Lysosome Transport Neuron-neuron Synaptic Transmission	Regulation Of Defense Response To Virus By Virus Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Viral Process Endosome To Melanosome Transport Pigment Granule Maturation Cellular Pigment Accumulation Membrane Organization Intracellular Protein Transport Negative Regulation Of Protein Localization To Plasma Membrane Melanosome Organization Pigment Granule Organization Regulation Of Immune System Process Clathrin-mediated Endocytosis Cellular Protein Localization Protein Transport Vesicle-mediated Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Negative Regulation Of ERBB Signaling Pathway Intracellular Transport Regulation Of Protein Localization To Plasma Membrane Cellular Pigmentation Developmental Pigmentation Response To External Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Localization Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Ephrin Receptor Signaling Pathway Immune System Process Pigmentation Cellular Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endosomal Transport Vesicle Organization Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Differentiation Golgi Vesicle Transport
Tagcloud ?		19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic	ala aromatic avoiding cd correct cytoplasmic degraded determinant diaromatic endosomal endosomes entering gradients impair internalized lysosomes missorted mpr neighboring percoll phe13 phe18 positions prove replacing sorting spacing tail trp19
Tagcloud (Difference) ?		19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 proximal separation similarity syntenic	ala aromatic avoiding cd correct cytoplasmic degraded determinant diaromatic endosomal endosomes entering gradients impair internalized lysosomes missorted mpr neighboring percoll phe13 phe18 prove replacing sorting spacing tail trp19
Tagcloud (Intersection) ?		positions