RTKN and MAP1LC3A

Number of citations of the paper that reports this interaction (PubMedID 19696020)
40

Data Source:
BioGRID (pull down)

		RTKN	MAP1LC3A
Description		rhotekin	microtubule associated protein 1 light chain 3 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Actomyosin Contractile Ring Cytosol	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Inhibitor Activity Protein Binding GTP Binding Small GTPase Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Signal Transduction Rho Protein Signal Transduction Septin Ring Organization Regulation Of Apoptotic Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Alanine aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		12 interacting genes: AKAP13 APP GOPC MAP1LC3A MFHAS1 RAC2 RHOA RHOB RHOC SMURF1 TAX1BP3 TGFBR1	100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304
Entrez ID		6242	84557
HPRD ID		03795	03144
Ensembl ID		ENSG00000114993	ENSG00000101460
Uniprot IDs		A0A1W2PPZ2 Q9BST9	Q9H492
PDB IDs			3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Skeletal Muscle Satellite Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Signal Transduction Regulation Of Actin Cytoskeleton Organization GTP Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Negative Regulation Of Protein Localization Supramolecular Fiber Organization Rho Protein Signal Transduction Positive Regulation Of Lipase Activity Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Apical Junction Assembly Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Actin Filament Organization Endothelial Tube Morphogenesis Negative Regulation Of Protein Localization To Cell Surface Regulation Of Cell Motility Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Modification Of Postsynaptic Structure GTPase Activity I-SMAD Binding Regulation Of Cell Projection Organization Response To Lead Ion Regulation Of Modification Of Synaptic Structure Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Copper Ion Positive Regulation Of Leukocyte Migration Regulation Of Intracellular Signal Transduction Extracellular Exosome Negative Regulation Of Signal Transduction Wound Healing, Spreading Of Cells Regulation Of Signal Transduction Regulation Of Protein Localization	Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity
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