RTKN and RHOC

Number of citations of the paper that reports this interaction (PubMedID 8662891)
0

Data Source:
HPRD (two hybrid)

		RTKN	RHOC
Description		rhotekin	ras homolog family member C
Image		No pdb structure
GO Annotations	Cellular Component	Actomyosin Contractile Ring Cytosol	Nucleus Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cleavage Furrow Stereocilium Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Inhibitor Activity Protein Binding GTP Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Signal Transduction Rho Protein Signal Transduction Septin Ring Organization Regulation Of Apoptotic Process	Mitotic Cytokinesis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Apical Junction Assembly Wound Healing, Spreading Of Cells Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOC GTPase cycle
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: AKAP13 APP GOPC MAP1LC3A MFHAS1 RAC2 RHOA RHOB RHOC SMURF1 TAX1BP3 TGFBR1	8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN
Entrez ID		6242	389
HPRD ID		03795	01322
Ensembl ID		ENSG00000114993	ENSG00000155366
Uniprot IDs		A0A1W2PPZ2 Q9BST9	A0A024R0C8 P08134
PDB IDs			1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Skeletal Muscle Satellite Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Signal Transduction Regulation Of Actin Cytoskeleton Organization GTP Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Negative Regulation Of Protein Localization Supramolecular Fiber Organization Rho Protein Signal Transduction Positive Regulation Of Lipase Activity Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Apical Junction Assembly Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Actin Filament Organization Endothelial Tube Morphogenesis Negative Regulation Of Protein Localization To Cell Surface Regulation Of Cell Motility Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Modification Of Postsynaptic Structure GTPase Activity I-SMAD Binding Regulation Of Cell Projection Organization Response To Lead Ion Regulation Of Modification Of Synaptic Structure Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Copper Ion Positive Regulation Of Leukocyte Migration Regulation Of Intracellular Signal Transduction Extracellular Exosome Negative Regulation Of Signal Transduction Wound Healing, Spreading Of Cells Regulation Of Signal Transduction Regulation Of Protein Localization	Small GTPase Binding Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signaling Cassette Negative Regulation Of Anoikis Actin Filament-based Process Regulation Of Anoikis Cell Death Apoptotic Process Programmed Cell Death Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Establishment Of Cell Polarity Membrane Raft Organization Cortical Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin-mediated Cell Contraction Regulation Of Cell Projection Assembly Regulation Of Organelle Organization Cortical Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process Inward Rectifier Potassium Channel Inhibitor Activity Actin Filament-based Movement Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Response To Peptide Hormone Response To Transforming Growth Factor Beta System Process Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Regulation Of Cellular Component Organization Regulation Of Developmental Process Caveolar Macromolecular Signaling Complex Positive Regulation Of Myeloid Dendritic Cell Activation Rho-dependent Protein Serine/threonine Kinase Activity Septin Ring Organization Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Regulation Of T Cell Activation Signaling Receptor Binding Protein Serine/threonine Kinase Activity Negative Regulation Of Endocytic Recycling Ruffle Positive Regulation Of Cell Junction Assembly Insulin Receptor Internalization Protein Localization To Basolateral Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?