RTKN and RHOB

Number of citations of the paper that reports this interaction (PubMedID 34187934)
69

Data Source:
BioGRID (proximity labelling technology, pull down)

		RTKN	RHOB
Description		rhotekin	ras homolog family member B
Image		No pdb structure
GO Annotations	Cellular Component	Actomyosin Contractile Ring Cytosol	Nucleus Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Cleavage Furrow Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Nucleotide Binding GTPase Inhibitor Activity Protein Binding GTP Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Signal Transduction Rho Protein Signal Transduction Septin Ring Organization Regulation Of Apoptotic Process	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosome To Lysosome Transport Positive Regulation Of Endothelial Cell Migration Protein Transport Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Regulation Of Modification Of Postsynaptic Structure
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle
Drugs			Botulinum toxin type A
Diseases
GWAS		Refractive error ( 32231278)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		12 interacting genes: AKAP13 APP GOPC MAP1LC3A MFHAS1 RAC2 RHOA RHOB RHOC SMURF1 TAX1BP3 TGFBR1	18 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PIAS1 PKN1 PPP2CA RHPN2 ROCK1 RTKN SMURF1 TNFAIP1 UBE2I ZKSCAN5
Entrez ID		6242	388
HPRD ID		03795	01321
Ensembl ID		ENSG00000114993	ENSG00000143878
Uniprot IDs		A0A1W2PPZ2 Q9BST9	P62745
PDB IDs			2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Skeletal Muscle Satellite Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Signal Transduction Regulation Of Actin Cytoskeleton Organization GTP Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Negative Regulation Of Protein Localization Supramolecular Fiber Organization Rho Protein Signal Transduction Positive Regulation Of Lipase Activity Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Apical Junction Assembly Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Actin Filament Organization Endothelial Tube Morphogenesis Negative Regulation Of Protein Localization To Cell Surface Regulation Of Cell Motility Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Modification Of Postsynaptic Structure GTPase Activity I-SMAD Binding Regulation Of Cell Projection Organization Response To Lead Ion Regulation Of Modification Of Synaptic Structure Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Copper Ion Positive Regulation Of Leukocyte Migration Regulation Of Intracellular Signal Transduction Extracellular Exosome Negative Regulation Of Signal Transduction Wound Healing, Spreading Of Cells Regulation Of Signal Transduction Regulation Of Protein Localization	Rho Protein Signal Transduction CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Modification Process Protein Geranylgeranyltransferase Activity Cytosol Protein Prenyltransferase Activity Small GTPase Binding Protein Geranylgeranylation Tau Protein Binding Protein Prenylation Prenyltransferase Activity Transferase Activity Mitotic Cytokinesis GTPase Inhibitor Activity Cytoskeleton-dependent Cytokinesis Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process SUMO Transferase Activity Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Cytoskeleton Organization Post-translational Protein Modification Actomyosin Structure Organization Renal System Process Negative Regulation Of Hippo Signaling Apoptotic Process Cytoplasm Regulation Of Protein Localization Cell Death Programmed Cell Death Presynaptic Cytosol Postsynaptic Cytosol Cortical Actin Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Epithelial Cell Migration Regulation Of Signal Transduction Signal Transduction System Process Neuromuscular Junction Development Microtubule Associated Complex Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Cell Surface Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Protein Modification By Small Protein Conjugation
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