GNAQ and GALR2

Number of citations of the paper that reports this interaction (PMID 9685625)
7

Data Source:
HPRD (in vivo)

		GNAQ	GALR2
Gene Name		guanine nucleotide binding protein (G protein), q polypeptide	galanin receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	Galanin Receptor Activity Protein Binding Peptide Hormone Binding
	Biological Process	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway	Muscle Contraction Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Multicellular Organismal Development Digestion Learning Or Memory Feeding Behavior Neuron Projection Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	2 interactors: GAL GNAQ
Entrez ID		2776	8811
HPRD ID		02998	04735
Ensembl ID			ENSG00000182687
Uniprot IDs		P50148	O43603
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling	Negative Regulation Of Root Hair Elongation Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity Positive Regulation Of Catagen Positive Regulation Of Cortisol Secretion Negative Regulation Of Lymphocyte Migration Protein Kinase A Signaling Behavior Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Positive Regulation Of Hair Follicle Development Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Glucocorticoid Metabolic Process Regulation Of Melanocyte Differentiation Maternal Behavior Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Hair Follicle Development Negative Regulation Of Leukocyte Migration CAMP-mediated Signaling Regulation Of Hair Cycle Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Response To Immobilization Stress Regulation Of Cellular Localization Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport G-protein Coupled Receptor Signaling Pathway Neuron Maturation Cyclic-nucleotide-mediated Signaling Regulation Of Lymphocyte Migration Positive Regulation Of Epidermis Development Positive Regulation Of Cation Channel Activity Regulation Of Hormone Metabolic Process Dopamine Receptor Signaling Pathway Forebrain Neuron Development Regulation Of Potassium Ion Transmembrane Transport Insulin Secretion Activation Of Phospholipase C Activity Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Cell Differentiation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Positive Regulation Of Lipid Transport Regulation Of Potassium Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Developmental Pigmentation Peptide Hormone Secretion
Tagcloud ?		adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	2specific antitumor benefits caspase3dependent cki cyclindependent d1 decreasing erk1 exerts extracellularregulated galanin galr1 head hnscc kinase1 ladder neck pertussis pretreatment reactivation reexpression suppressed suppresses suppressors toxin u0126
Tagcloud (Difference) ?		adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	2specific antitumor benefits caspase3dependent cki cyclindependent d1 decreasing erk1 exerts extracellularregulated galanin galr1 head hnscc kinase1 ladder neck pertussis pretreatment reactivation reexpression suppressed suppresses suppressors toxin u0126
Tagcloud (Intersection) ?