GNAQ and TUB

Number of citations of the paper that reports this interaction (PubMedID 11375483)
0

Data Source:
HPRD (in vitro)

		GNAQ	TUB
Description		G protein subunit alpha q	TUB bipartite transcription factor
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Membrane Nuclear Membrane Extracellular Exosome Postsynaptic Cytosol	Extracellular Region Nucleus Cytoplasm Cytosol Plasma Membrane Cilium Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity GTPase Activator Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Receptor Binding Protein-containing Complex Binding Intraciliary Transport Particle A Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Hormone-mediated Signaling Pathway Regulation Of Platelet Activation Response To Prostaglandin E Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Acidic PH Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway	Phagocytosis Phagocytosis, Recognition Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Intraciliary Transport Photoreceptor Cell Maintenance Positive Regulation Of Phagocytosis Retina Development In Camera-type Eye Protein Localization To Cilium Receptor Localization To Non-motile Cilium Protein Localization To Photoreceptor Outer Segment
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			(1R,2R,3S,4R,6S)-3,4,6-Trihydroxy-5-{[(S)-hydroxy(3-hydroxy-2-oxopropoxy)phosphoryl]oxy}-1,2-cyclohexanediyl bis[dihydrogen (phosphate)]
Diseases
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Age-related hearing impairment ( 34108613) Body mass index ( 20935630 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Coronary artery disease in type 1 diabetes ( 29695241) Familial lung adenocarcinoma ( 29924316) Familial lung cancer ( 29924316) Malaria ( 31844061)
Interacting Genes		48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NHERF1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 TBXA2R TSHR TTC1 TUB VIPR1	9 interacting genes: ABL1 GNAQ GRB2 IRS1 JAK2 LCK PIK3R1 PLCG1 SRC
Entrez ID		2776	7275
HPRD ID		02998	03121
Ensembl ID		ENSG00000156052	ENSG00000166402
Uniprot IDs		A0A024R240 P50148	P50607
PDB IDs		6VU5 7EZM 7F6G 7F6H 7F6I 7F8W 7W3Z 7W40 7XOW 8G59 8IA7 8IYS 8J9N 8JPB 8JPC 8JPE 8SZG 8UQN 8UQO 8XGO 8XGS 8Y52 8ZJD 8ZJE 9K27	1S31
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Regulation Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality System Process Serotonin Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Membrane G Protein-coupled Serotonin Receptor Activity Cell-cell Signaling Regulation Of Amine Transport Regulation Of Sequestering Of Calcium Ion G Protein-coupled Serotonin Receptor Complex Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Cell Communication Calcium Ion Transmembrane Import Into Cytosol Regulation Of System Process G Protein-coupled Serotonin Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Muscle System Process GTPase Activator Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Secretion Phospholipase C-activating Serotonin Receptor Signaling Pathway Muscle Contraction Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Serotonin Binding Guanyl-nucleotide Exchange Factor Activity Regulation Of Secretion By Cell	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway SH2 Domain Binding Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Binding Neurotrophin TRKA Receptor Binding Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Substrate Binding ERBB Signaling Pathway Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Leukocyte Activation Positive Regulation Of T Cell Activation Intracellular Signal Transduction Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation Regulation Of Cell Activation Cell Activation Positive Regulation Of Immune Response Ephrin Receptor Binding Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of T Cell Activation T Cell Differentiation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Immune Effector Process Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Protein Kinase Binding T Cell Costimulation Substrate Adhesion-dependent Cell Spreading Lymphocyte Activation Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway
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