GNAQ and RGS5

Number of citations of the paper that reports this interaction (PMID 11253162)
15

Data Source:
HPRD (in vivo)

		GNAQ	RGS5
Gene Name		guanine nucleotide binding protein (G protein), q polypeptide	regulator of G-protein signaling 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	GTPase Activator Activity
	Biological Process	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway	Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	6 interactors: ADRB2 APP GNAI2 GNAI3 GNAO1 GNAQ
Entrez ID		2776	8490
HPRD ID		02998	04471
Ensembl ID			ENSG00000143248
Uniprot IDs		P50148	O15539
PDB IDs			2CRP
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of Catalytic Activity Regulation Of CAMP Metabolic Process Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Neuron Remodeling Regulation Of Body Fluid Levels Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Wound Healing Positive Regulation Of Catalytic Activity Cell Activation Response To Stress Response To Wounding Negative Regulation Of Adenylate Cyclase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Lyase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of CAMP Biosynthetic Process Neuron Maturation Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Regulation Of Protein Phosphorylation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Signal Transduction Forebrain Development Regulation Of Phosphorylation Signaling Cell Communication Regulation Of Multicellular Organism Growth Behavior Positive Regulation Of Metabolic Process Regulation Of Ion Transport Cellular Response To Stimulus Synaptic Growth At Neuromuscular Junction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Protein Binding Cell Maturation Regulation Of Cellular Protein Metabolic Process Brain Development
Tagcloud ?		adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	allergen asm asthma asthmatic attributable bronchial bundles carbachol challenged contractile contraction copious gpcr gpcrs histamine hyperplastic hypertrophic mobilization mucus myocyte nonrespiratory obstruction paradoxically postmortem postreceptor procontractile shortening slices thrombin
Tagcloud (Difference) ?		adaptor contributing driving extensively flies gna11 gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	allergen asm asthma asthmatic attributable bronchial bundles carbachol challenged contractile contraction copious gpcr histamine hyperplastic hypertrophic mobilization mucus myocyte nonrespiratory obstruction paradoxically postmortem postreceptor procontractile shortening slices thrombin
Tagcloud (Intersection) ?		gpcrs