GNAQ and RGS18

Number of citations of the paper that reports this interaction (PMID 11955952)
14

Data Source:
HPRD (in vitro)

		GNAQ	RGS18
Gene Name		guanine nucleotide binding protein (G protein), q polypeptide	regulator of G-protein signaling 18
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	GTPase Activator Activity
	Biological Process	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway	G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	5 interactors: APP GNAI1 GNAI2 GNAI3 GNAQ
Entrez ID		2776	64407
HPRD ID		02998	06224
Ensembl ID			ENSG00000150681
Uniprot IDs		P50148	Q9NS28
PDB IDs			2DLV 2JM5 2OWI
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling	Platelet Activation Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Neuron Remodeling Negative Regulation Of Catalytic Activity Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Neuron Maturation Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Vesicle Fusion Regulation Of Adenylate Cyclase Activity Cell Division Glutamate Receptor Signaling Pathway Response To Stress Regulation Of Phosphorus Metabolic Process Regulation Of Cyclase Activity Organelle Fusion Regulation Of CAMP Biosynthetic Process Synaptic Transmission Regulation Of CAMP Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Membrane Fusion Regulation Of Kinase Activity Cell Maturation Synaptic Growth At Neuromuscular Junction Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Collateral Sprouting In Absence Of Injury Vesicle Organization Signaling Regulation Of Protein Phosphorylation Cell Communication Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Phosphorylation
Tagcloud ?		adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	3gamma a2 activates adp amp block cyclic detachment gmp gq gtpase heterotrimeric nitric pka pkgi platelet platelets pronounced prostacyclin q serine serines stimulates stores talk thrombin thromboxane trigger turns
Tagcloud (Difference) ?		adaptor contributing driving extensively flies gna11 gpcrs guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	3gamma a2 activates adp amp block cyclic detachment gmp gtpase heterotrimeric nitric pka pkgi platelet platelets pronounced prostacyclin q serine serines stimulates stores talk thrombin thromboxane trigger turns
Tagcloud (Intersection) ?		gq