GNAQ and S1PR2

Number of citations of the paper that reports this interaction (PMID 10488065)
54

Data Source:
HPRD (in vitro)

		GNAQ	S1PR2
Gene Name		guanine nucleotide binding protein (G protein), q polypeptide	sphingosine-1-phosphate receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	G-protein Coupled Receptor Binding G-protein Coupled Receptor Activity Integrin Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway	Activation Of MAPK Activity Sphingosine-1-phosphate Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	3 interactors: GNA13 GNAI1 GNAQ
Entrez ID		2776	9294
HPRD ID		02998	05488
Ensembl ID
Uniprot IDs		P50148	O95136
PDB IDs			1ZTI
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Wound Healing Cell Activation Response To Wounding Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Regulation Of Melanocyte Differentiation Activation Of Phospholipase D Activity Maternal Behavior Cell Surface Receptor Signaling Pathway Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Response To Stress Neuron Maturation Cardiovascular System Development Dopamine Receptor Signaling Pathway Forebrain Neuron Development Positive Regulation Of Hydrolase Activity Patterning Of Blood Vessels Activation Of Phospholipase C Activity Vesicle Fusion Embryo Development Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Developmental Pigmentation Embryonic Digit Morphogenesis Organelle Fusion Forebrain Generation Of Neurons Action Potential Signal Transduction Protein Stabilization Positive Regulation Of Catalytic Activity Signaling Central Nervous System Neuron Development Cell Communication Pigmentation
Tagcloud ?		adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	altogether bioactive chl contiguous dissemination fty720 functionally gi governs h2 hd1 heterotrimeric hodgkin jte013 km lymphatic lymphoma membranous neoplasm potentiated potently reed s1pr1 sphingolipid sphingosine sternberg sup vpc44116
Tagcloud (Difference) ?		adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	altogether bioactive chl contiguous dissemination fty720 functionally gi governs h2 hd1 heterotrimeric hodgkin jte013 km lymphatic lymphoma membranous neoplasm potentiated potently reed s1pr1 sphingolipid sphingosine sternberg sup vpc44116
Tagcloud (Intersection) ?