GNAQ and S1PR3

Number of citations of the paper that reports this interaction (PubMedID 10488065)
0

Data Source:
HPRD (in vitro)

		GNAQ	S1PR3
Description		G protein subunit alpha q	sphingosine-1-phosphate receptor 3
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Membrane Nuclear Membrane Extracellular Exosome Postsynaptic Cytosol	Cytoplasm Plasma Membrane Membrane Presynapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity GTPase Activator Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Receptor Activity Integrin Binding Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Hormone-mediated Signaling Pathway Regulation Of Platelet Activation Response To Prostaglandin E Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Acidic PH Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway	Sphingosine-1-phosphate Receptor Signaling Pathway Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Notch Signaling Pathway Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Establishment Of Endothelial Barrier
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	G alpha (i) signalling events Lysosphingolipid and LPA receptors Extra-nuclear estrogen signaling
Drugs			Fingolimod
Diseases
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Cardiometabolic and hematological traits ( 27668658) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte percentage of white cells ( 27863252 32888494) Response to statins (LDL cholesterol change) ( 22331829) Spleen volume ( 34128465) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NHERF1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 TBXA2R TSHR TTC1 TUB VIPR1	6 interacting genes: COMT GNA13 GNAI1 GNAQ GYPB HTR1A
Entrez ID		2776	1903
HPRD ID		02998	03572
Ensembl ID		ENSG00000156052	ENSG00000213694
Uniprot IDs		A0A024R240 P50148	Q99500
PDB IDs		6VU5 7EZM 7F6G 7F6H 7F6I 7F8W 7W3Z 7W40 7XOW 8G59 8IA7 8IYS 8J9N 8JPB 8JPC 8JPE 8SZG 8UQN 8UQO 8XGO 8XGS 8Y52 8ZJD 8ZJE 9K27	7C4S 7EW2 7EW3 7EW4
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Regulation Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality System Process Serotonin Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Membrane G Protein-coupled Serotonin Receptor Activity Cell-cell Signaling Regulation Of Amine Transport Regulation Of Sequestering Of Calcium Ion G Protein-coupled Serotonin Receptor Complex Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Cell Communication Calcium Ion Transmembrane Import Into Cytosol Regulation Of System Process G Protein-coupled Serotonin Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Muscle System Process GTPase Activator Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Secretion Phospholipase C-activating Serotonin Receptor Signaling Pathway Muscle Contraction Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Serotonin Binding Guanyl-nucleotide Exchange Factor Activity Regulation Of Secretion By Cell	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Ketone Response To Prostaglandin E Behavioral Fear Response Exploration Behavior Behavioral Defense Response Response To Alcohol G Protein-coupled Receptor Signaling Pathway Fear Response GTPase Activity GTP Binding Multicellular Organismal Response To Stress Norepinephrine Secretion Catechol O-methyltransferase Activity Phenol-containing Compound Metabolic Process Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Neuropeptide Signaling Pathway Cellular Response To Phosphate Starvation D5 Dopamine Receptor Binding Detection Of Abiotic Stimulus Response To Hormone D2 Dopamine Receptor Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Receptor-receptor Interaction Regulation Of Blood Pressure Cerebellar Cortex Morphogenesis Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Serotonin Secretion Response To Lipid Dopamine Secretion Positive Regulation Of Protein Localization To Cell Cortex
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