GNAQ and ADRA1B

Number of citations of the paper that reports this interaction (PMID 9481484)
1

Data Source:
HPRD (in vivo)

		GNAQ	ADRA1B
Gene Name		guanine nucleotide binding protein (G protein), q polypeptide	adrenoceptor alpha 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	Alpha1-adrenergic Receptor Activity Protein Heterodimerization Activity
	Biological Process	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway	Blood Vessel Remodeling Response To Amphetamine Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Adult Heart Development Locomotory Behavior Cell Proliferation Visual Learning Cell Growth Regulation Of Vasoconstriction Organ Growth Intracellular Signal Transduction Glucose Homeostasis Response To Morphine Positive Regulation Of MAPK Cascade Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycogen Catabolic Process Behavioral Response To Cocaine Regulation Of Cardiac Muscle Contraction Adrenergic Receptor Signaling Pathway
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Adrenoceptors G alpha (12/13) signalling events
Drugs			Midodrine Ziprasidone Dapiprazole Olanzapine Alfuzosin Clozapine Norepinephrine Phenylephrine Promazine Prazosin Chlorpromazine Doxazosin Labetalol Nicardipine Epinephrine Thioridazine Ergotamine Tamsulosin Methoxamine Trimipramine Risperidone Modafinil Propiomazine Doxepin Nefazodone Terazosin Pergolide Bromocriptine Quetiapine Aripiprazole Lisdexamfetamine Paliperidone Methotrimeprazine Dextroamphetamine Phendimetrazine Propericiazine Acepromazine Thioproperazine Dronedarone Sertindole Silodosin Droxidopa Xylometazoline
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	11 interactors: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1
Entrez ID		2776	147
HPRD ID		02998	00080
Ensembl ID
Uniprot IDs		P50148	P35368
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling	Regulation Of The Force Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To External Stimulus Developmental Process Positive Regulation Of Phospholipase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Melanocyte Differentiation Negative Regulation Of Catalytic Activity Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Filopodium Assembly Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signal Transduction Regulation Of Muscle Contraction Regulation Of Developmental Pigmentation Regulation Of Heart Contraction Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Intracellular Signal Transduction Signaling Platelet Activation Rhodopsin Mediated Signaling Pathway System Development Cell Communication G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Signaling Wound Healing Dopamine Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Locomotion Response To Stimulus Response To Wounding Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Multicellular Organismal Development Regulation Of Catalytic Activity Cellular Response To Stimulus
Tagcloud ?		adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital
Tagcloud (Difference) ?		adaptor contributing driving extensively flies gna11 gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap	adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital
Tagcloud (Intersection) ?		gpcrs