PCGF2 and UBE2T

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		PCGF2	UBE2T
Gene Name		polycomb group ring finger 2	ubiquitin-conjugating enzyme E2T
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding	Chromatin Binding Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Anterior/posterior Pattern Specification Protein Ubiquitination Histone Acetylation Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways			Fanconi Anemia pathway
Drugs
Diseases
GWAS			Breast cancer ( 23535733)
Protein-Protein Interactions		23 interactors: ABHD6 CBX6 CBX7 CBX8 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7	14 interactors: AMFR ARIH2 BRCA1 FANCL LNX2 MARCH5 MGRN1 PCGF2 RNF128 RNF144B RNF4 TRIM27 UBA1 UBA6
Entrez ID		7703	29089
HPRD ID		10621	13704
Ensembl ID		ENSG00000056661	ENSG00000077152
Uniprot IDs		P35227	Q9NPD8
PDB IDs			1YH2
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Chromatin Modification Chromatin Organization Protein Polyubiquitination Histone Modification Chromosome Organization Protein K48-linked Ubiquitination Protein Monoubiquitination Histone H2A Monoubiquitination Cellular Protein Modification Process Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Histone Monoubiquitination Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Sterol Regulatory Element Binding Protein Import Into Nucleus RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Anterior/posterior Pattern Specification Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Catabolic Process Regulation Of Gene Expression Protein Linear Polyubiquitination Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K63-linked Ubiquitination Protein Autoubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K6-linked Ubiquitination Proteolysis Cellular Metabolic Process Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Protein Monoubiquitination Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Stress Regulation Of Kinetochore Assembly Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Centromere Complex Assembly Protein Oligomerization Regulation Of Cytoskeleton Organization Cellular Response To Indole-3-methanol Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Centriole Replication Negative Regulation Of Calcium Ion Import Regulation Of Cytokine Production Dosage Compensation By Inactivation Of X Chromosome Regulation Of Microtubule-based Process Negative Regulation Of CAMP-mediated Signaling Interferon-gamma Secretion Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Metabolic Process
Tagcloud ?		acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Difference) ?		acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Intersection) ?