PCGF2 and CD247

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PCGF2	CD247
Gene Name		polycomb group ring finger 2	CD247 molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Anterior/posterior Pattern Specification Protein Ubiquitination Histone Acetylation Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		23 interactors: ABHD6 CBX6 CBX7 CBX8 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		7703	919
HPRD ID		10621	01729
Ensembl ID		ENSG00000056661	ENSG00000198821
Uniprot IDs		P35227	P20963
PDB IDs			1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Chromatin Modification Chromatin Organization Protein Polyubiquitination Histone Modification Chromosome Organization Protein K48-linked Ubiquitination Protein Monoubiquitination Histone H2A Monoubiquitination Cellular Protein Modification Process Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Histone Monoubiquitination Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Sterol Regulatory Element Binding Protein Import Into Nucleus RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Anterior/posterior Pattern Specification Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Catabolic Process Regulation Of Gene Expression Protein Linear Polyubiquitination Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?		encode