CBX7 and SUV39H2

Number of citations of the paper that reports this interaction (PMID 21060834)
12

Data Source:
BioGRID (protein complementation assay)

		CBX7	SUV39H2
Gene Name		chromobox homolog 7	suppressor of variegation 3-9 homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm PcG Protein Complex PRC1 Complex	Chromosome, Centromeric Region Chromatin Nucleoplasm Nuclear Heterochromatin
	Molecular Function	Chromatin Binding Single-stranded RNA Binding Protein Binding Methylated Histone Binding	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification Sebaceous Gland Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Assembly Or Disassembly Chromatin Remodeling Transcription, DNA-templated Male Meiosis Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: B3GNT5 BMI1 HIST3H3 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 RING1 RNF2 SUV39H2	39 interactors: AKAP9 APPL2 BLZF1 C8orf74 CBX5 CBX7 CCDC151 CCDC37 CDCA4 CEP70 CGGBP1 EWSR1 FAM20C GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MCM3AP MRFAP1 MTF2 MYL12A NME4 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57
Entrez ID		23492	79723
HPRD ID		12234	07580
Ensembl ID		ENSG00000100307	ENSG00000152455
Uniprot IDs		B0QYP2 O95931	Q9H5I1
PDB IDs		2K1B 2L12 2L1B 3GS2	2R3A
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Histone Modification Histone H2A Monoubiquitination Histone H2A Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Chromosome Organization Macromolecule Biosynthetic Process Histone Monoubiquitination Chromatin Modification Chromatin Organization RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Protein Monoubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Protein Ubiquitination Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Pattern Specification Process Cellular Metabolic Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Peptidyl-lysine Modification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Histone H2A-K119 Monoubiquitination Cellular Protein Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Immature T Cell Proliferation In Thymus	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K27 Methylation Regulation Of RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Osteoblast Differentiation Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Golgi To Plasma Membrane Transport Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Osteoclast Maturation Regulation Of Histone Methylation Regulation Of Ossification Protein Targeting Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Establishment Of Protein Localization To Membrane Positive Regulation Of DNA Replication Positive Regulation Of Histone Modification Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Osteoblast Differentiation Myeloid Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition
Tagcloud ?		able acquisition acts carcinomas chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive spp1 suppose take transcriptional whose	a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Difference) ?		able acquisition acts carcinomas chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive spp1 suppose take transcriptional whose	a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Intersection) ?