CBX7 and PCGF5

Number of citations of the paper that reports this interaction (PubMedID 21282530)
78

Data Source:
BioGRID (pull down)

		CBX7	PCGF5
Description		chromobox 7	polycomb group ring finger 5
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol PcG Protein Complex PRC1 Complex	X Chromosome Nucleus Nucleoplasm Golgi Apparatus Centrosome PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Random Inactivation Of X Chromosome
Pathways			RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Lymphocyte count ( 27863252 32888494) Menarche (age at onset) ( 25231870) Multiple myeloma ( 23955597 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil count ( 32888494) White blood cell count ( 27863252 32888494)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		12 interacting genes: B3GNT5 H3-3A H3-4 H3C1 H3C14 PCGF1 PCGF5 PCGF6 RING1 RNF2 SUV39H2 ZRANB1	9 interacting genes: CBX7 CBX8 DHX57 PRMT6 QKI TRAF2 TRIM8 UBE2D3 USP10
Entrez ID		23492	84333
HPRD ID		12234	17825
Ensembl ID		ENSG00000100307	ENSG00000180628
Uniprot IDs		B0QYP2 O95931 Q4PNR6	Q86SE9
PDB IDs		2K1B 2L12 2L1B 3GS2 4MN3 5EPJ 6V2R 8SII	4S3O
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex Structural Constituent Of Chromatin Nucleoplasm Nucleosome Assembly Epigenetic Regulation Of Gene Expression Nucleosome Nucleosome Organization Histone H2AK119 Ubiquitin Ligase Activity Chromosome Protein-DNA Complex Assembly Sex Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Activity Regulation Of Gene Expression Gene Expression Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Chromosome Condensation Regulation Of Macromolecule Metabolic Process Ubiquitin Ligase Complex Spermatogonial Cell Division Protein K29-linked Deubiquitination Histone H3K9 Trimethyltransferase Activity X Chromosome Pericentric Heterochromatin Formation Telomere Organization Protein K33-linked Deubiquitination Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Centromere Complex Assembly Heterochromatin Formation	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PRC1 Complex Regulation Of Metabolic Process PcG Protein Complex Stress Granule Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Ubiquitination Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Protein Polyubiquitination TORC2 Complex Disassembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process MRNA Stabilization Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Chromatin Organization Internal N(7)-methylguanine-containing RNA Reader Activity Histone H2AR3 Methyltransferase Activity Ubiquitin Protein Ligase Activity Regulation Of Macromolecule Metabolic Process Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stress Granule Assembly Myofibroblast Contraction Negative Regulation Of MiRNA Catabolic Process Histone H3R2 Methyltransferase Activity Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Histone Arginine N-methyltransferase Activity Response To Stress Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex DNA Repair
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