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KLHL12 and PEF1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KLHL12
PEF1
Gene Name
kelch-like family member 12
penta-EF-hand domain containing 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Cytoplasm
Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Poly(A) RNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
Biological Process
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Proteolysis
Response To Calcium Ion
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
11 interactors:
ALG2
CALCOCO2
CEP55
DAZAP2
EWSR1
FOXR2
HGS
KLHL12
NR0B2
PDCD6
TFG
Entrez ID
59349
553115
HPRD ID
13925
10143
Ensembl ID
ENSG00000117153
ENSG00000162517
Uniprot IDs
Q53G59
Q9UBV8
PDB IDs
2VPJ
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of TOR Signaling
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Endothelial Cell Migration
Regulation Of TOR Signaling
Positive Regulation Of Endothelial Cell Proliferation
Cellular Response To Heat
Protein Glycosylation In Endoplasmic Reticulum
Positive Regulation Of Epithelial Cell Migration
Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Zymogen Activation
Regulation Of Endothelial Cell Migration
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Signaling
Response To Heat
Response To Calcium Ion
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Protein Kinase B Signaling
Positive Regulation Of Angiogenesis
Positive Regulation Of Endopeptidase Activity
Regulation Of Epithelial Cell Migration
Positive Regulation Of Peptidase Activity
Positive Regulation Of Epithelial Cell Proliferation
Establishment Of Protein Localization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Transport
Regulation Of Cellular Response To Growth Factor Stimulus
Response To Temperature Stimulus
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Signal Transduction
Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Angiogenesis
Regulation Of Intracellular Signal Transduction
Protein Processing
Positive Regulation Of Exosomal Secretion
Regulation Of Exosomal Secretion
Protein Targeting To Lysosome
Enzyme Linked Receptor Protein Signaling Pathway
Intracellular Protein Transport
Protein Localization
Protein Localization To Lysosome
Tagcloud
?
adl
aia
alfalfa
concentrate
contemporary
detergent
digestibility
fibre
fibres
forage
forages
haylage
insoluble
lactation
lignin
ndf
nel
pef8
pendf
pendf1
pendf8
penn
psps
ration
separator
sieves
silage
tmrs
Tagcloud (Difference)
?
adl
aia
alfalfa
concentrate
contemporary
detergent
digestibility
fibre
fibres
forage
forages
haylage
insoluble
lactation
lignin
ndf
nel
pef8
pendf
pendf1
pendf8
penn
psps
ration
separator
sieves
silage
tmrs
Tagcloud (Intersection)
?