PEF1 and KLHL12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PEF1	KLHL12
Gene Name		penta-EF-hand domain containing 1	kelch-like family member 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane Extracellular Vesicular Exosome	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Poly(A) RNA Binding Protein Heterodimerization Activity Protein Dimerization Activity	Protein Binding
	Biological Process	Proteolysis Response To Calcium Ion	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ALG2 CALCOCO2 CEP55 DAZAP2 EWSR1 FOXR2 HGS KLHL12 NR0B2 PDCD6 TFG	39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1
Entrez ID		553115	59349
HPRD ID		10143	13925
Ensembl ID		ENSG00000162517	ENSG00000117153
Uniprot IDs		Q9UBV8	Q53G59
PDB IDs			2VPJ
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Endothelial Cell Migration Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Heat Protein Glycosylation In Endoplasmic Reticulum Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Negative Regulation Of Intracellular Signal Transduction Regulation Of Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Zymogen Activation Regulation Of Endothelial Cell Migration Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Response To Heat Response To Calcium Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Kinase B Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Endopeptidase Activity Regulation Of Epithelial Cell Migration Positive Regulation Of Peptidase Activity Positive Regulation Of Epithelial Cell Proliferation Establishment Of Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Transport Regulation Of Cellular Response To Growth Factor Stimulus Response To Temperature Stimulus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Angiogenesis Regulation Of Intracellular Signal Transduction Protein Processing Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Protein Localization Protein Localization To Lysosome	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division
Tagcloud ?		adl aia alfalfa concentrate contemporary detergent digestibility fibre fibres forage forages haylage insoluble lactation lignin ndf nel pef8 pendf pendf1 pendf8 penn psps ration separator sieves silage tmrs
Tagcloud (Difference) ?		adl aia alfalfa concentrate contemporary detergent digestibility fibre fibres forage forages haylage insoluble lactation lignin ndf nel pef8 pendf pendf1 pendf8 penn psps ration separator sieves silage tmrs
Tagcloud (Intersection) ?