PEF1 and PDCD6

Number of citations of the paper that reports this interaction (PMID 11278427)
11

Data Source:
HPRD (in vivo)

		PEF1	PDCD6
Gene Name		penta-EF-hand domain containing 1	programmed cell death 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Poly(A) RNA Binding Protein Heterodimerization Activity Protein Dimerization Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity Protein Anchor Protein Dimerization Activity Calcium-dependent Protein Binding Binding, Bridging
	Biological Process	Proteolysis Response To Calcium Ion	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Proteolysis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ALG2 CALCOCO2 CEP55 DAZAP2 EWSR1 FOXR2 HGS KLHL12 NR0B2 PDCD6 TFG	18 interactors: ANXA11 ANXA7 CDKN2A CPNE1 CPNE2 CPNE4 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 SH3KBP1 TIMM22 VPS37C YWHAQ
Entrez ID		553115	10016
HPRD ID		10143	03035
Ensembl ID		ENSG00000162517	ENSG00000249915
Uniprot IDs		Q9UBV8	O75340 Q53FC3
PDB IDs			2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Endothelial Cell Migration Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Heat Protein Glycosylation In Endoplasmic Reticulum Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Negative Regulation Of Intracellular Signal Transduction Regulation Of Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Zymogen Activation Regulation Of Endothelial Cell Migration Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Response To Heat Response To Calcium Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Kinase B Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Endopeptidase Activity Regulation Of Epithelial Cell Migration Positive Regulation Of Peptidase Activity Positive Regulation Of Epithelial Cell Proliferation Establishment Of Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Transport Regulation Of Cellular Response To Growth Factor Stimulus Response To Temperature Stimulus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Angiogenesis Regulation Of Intracellular Signal Transduction Protein Processing Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Protein Localization Protein Localization To Lysosome	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Cell Death Death Positive Regulation Of Peptidase Activity Programmed Necrotic Cell Death Necrotic Cell Death Necroptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Inorganic Substance Membrane Organization Inflammatory Cell Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Response To Metal Ion Response To Calcium Ion Apoptotic Signaling Pathway T Cell Apoptotic Process Cell Separation After Cytokinesis Regulation Of Endopeptidase Activity Virion Assembly Regulation Of Peptidase Activity Necroptotic Process Regulation Of Cell Death Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Mitochondrial Membrane Organization Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Regulation Of ERBB Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Motor Neuron Apoptotic Process Regulation Of Apoptotic Process Mitochondrion Organization Cytokinesis, Completion Of Separation Senescence-associated Heterochromatin Focus Assembly Endosomal Lumen Acidification
Tagcloud ?		adl aia alfalfa concentrate contemporary detergent digestibility fibre fibres forage forages haylage insoluble lactation lignin ndf nel pef8 pendf pendf1 pendf8 penn psps ration separator sieves silage tmrs	adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Difference) ?		adl aia alfalfa concentrate contemporary detergent digestibility fibre fibres forage forages haylage insoluble lactation lignin ndf nel pef8 pendf pendf1 pendf8 penn psps ration separator sieves silage tmrs	adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
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