PEF1 and ALG2

Number of citations of the paper that reports this interaction (PubMedID 12804766)
0

Data Source:
HPRD (two hybrid, in vitro)

		PEF1	ALG2
Description		penta-EF-hand domain containing 1	ALG2 alpha-1,3/1,6-mannosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development COPII Vesicle Coating Response To Calcium Ion Positive Regulation Of Protein Monoubiquitination	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG2 causes CDG-1i
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566) Hypoalbuminemia ( 34050200) Intelligence (MTAG) ( 29326435) Severe aortic features in Marfan syndrome ( 30087447)	Asthma ( 31959851 34103634) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		40 interacting genes: AKAP8L ALG2 ANKRD10 BAG4 BPIFA1 CALCOCO2 CEP55 CFAP68 CTAG1A CTAG1B DAZAP2 DMRTB1 EIF4G1 EWSR1 FAM168A FOXR2 HEMK1 HGS HYDIN INCA1 KRTAP12-1 KRTAP15-1 KRTAP19-1 MED25 METTL15 NR0B2 PDCD6 SEC24A SEC31A SMUG1 SOHLH1 SPAG8 SPG21 STH TFG UBC USP9X VPS37C WWOX ZIC1	4 interacting genes: ANXA11 PEF1 PTPN23 SRI
Entrez ID		553115	85365
HPRD ID		10143	09716
Ensembl ID		ENSG00000162517	ENSG00000119523
Uniprot IDs		A0A384MQX5 Q9UBV8	A0A0A0MTE0 Q9H553
PDB IDs		8RBH
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Exit Site COPII Vesicle Coat Protein Binding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport	Calcium-dependent Protein Binding Extracellular Exosome Calcium Ion Binding Positive Regulation Of Homophilic Cell Adhesion Response To Calcium Ion Positive Regulation Of Adherens Junction Organization Vesicle-mediated Transport Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of Wnt Protein Secretion Regulation Of Adherens Junction Organization Regulation Of Homophilic Cell Adhesion Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Secretion Regulation Of Protein Monoubiquitination Negative Regulation Of Striated Muscle Contraction Chromaffin Granule Membrane Neural Crest Formation Response To Metal Ion Positive Regulation Of Early Endosome To Late Endosome Transport Protein Heterodimerization Activity Azurophil Granule Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Phosphatidylethanolamine Binding S100 Protein Binding Specific Granule Regulation Of Cell Communication By Electrical Coupling Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Regulation Of Protein Transport Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Epithelial Cell Migration COPII Vesicle Coat Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Regulation Of Establishment Of Protein Localization Negative Regulation Of Blood Circulation Regulation Of Cellular Localization Early Endosome To Late Endosome Transport COPII Vesicle Coating MHC Class II Protein Complex Binding Regulation Of Secretion By Cell Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Neural Crest Cell Development Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Cardiac Muscle Cell Contraction Regulation Of Secretion Vesicle Membrane Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
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