DRD4 and ETNK1

		DRD4	ETNK1
Description		dopamine receptor D4	ethanolamine kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Membrane
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding	Nucleotide Binding Ethanolamine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Adult Behavior Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonate Secretion Negative Regulation Of Protein Secretion Regulation Of Transport Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Lipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phospholipid Biosynthetic Process
Pathways		Dopamine receptors G alpha (i) signalling events	Synthesis of PE
Drugs		Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Nandrolone decanoate Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS			Automobile speeding propensity ( 30643258) Chronotype ( 30696823) Mortality in sepsis ( 27639821) Precuneus cortex volume ( 31530798) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		9 interacting genes: ADCY2 ADRB2 CLIC6 GABRA1 GNAI1 GRB2 KCNJ9 KLHL12 NCK1	6 interacting genes: CAMLG SGTA SGTB SLC51B UBQLN1 UBQLN2
Entrez ID		1815	55500
HPRD ID		00541	09934
Ensembl ID		ENSG00000069696	ENSG00000139163
Uniprot IDs		P21917	Q86U68 Q9HBU6
PDB IDs		5WIU 5WIV
Enriched GO Terms of Interacting Partners?		D2 Dopamine Receptor Binding Adenylate Cyclase Binding Response To Forskolin Cellular Response To Forskolin Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ephrin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Chloride Channel Complex Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Molecular Condensate Scaffold Activity D4 Dopamine Receptor Binding Nucleotide Binding Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Biological Quality Regulation Of Organelle Organization Beta2-adrenergic Receptor Activity Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation GABA Receptor Complex Chloride Channel Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation D3 Dopamine Receptor Binding Ethanolamine Kinase Activity	Positive Regulation Of ERAD Pathway TRC Complex Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization To Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteolysis Protein Targeting To ER Positive Regulation Of Protein Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Metabolic Process Identical Protein Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Insertion Into Membrane Protein Targeting To Membrane Regulation Of Receptor Internalization Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Autophagosome Negative Regulation Of Transport Autophagosome Assembly Proteasomal Protein Catabolic Process Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Localization Within Membrane Regulation Of Cellular Response To Stress GET Complex Negative Regulation Of Protein Catabolic Process Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Receptor-mediated Endocytosis Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Monocarboxylic Acid Transport Positive Regulation Of Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Proteolysis Protein Catabolic Process Regulation Of Protein Modification Process
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