DRD4 and CARS1

Data Source: HiPPIP (Novel)

		DRD4	CARS1
Name		dopamine receptor D4	cysteinyl-tRNA synthetase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Centrosome Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Ligase Activity Cysteine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Adult Behavior Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonate Secretion Negative Regulation Of Protein Secretion Regulation Of Transport Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Translation TRNA Aminoacylation For Protein Translation Cysteinyl-tRNA Aminoacylation
Pathways		Dopamine receptors G alpha (i) signalling events	Cytosolic tRNA aminoacylation Signaling by ALK fusions and activated point mutants
Drugs		Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Nandrolone decanoate Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil	Cysteine
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		9 interacting genes: ADCY2 ADRB2 CLIC6 GABRA1 GNAI1 GRB2 KCNJ9 KLHL12 NCK1	7 interacting genes: APP EEF1G PTP4A2 RNF10 SUMO2 TRIM55 TRIM63
Entrez ID		1815	833
HPRD ID		00541	00464
Ensembl ID		ENSG00000069696	ENSG00000110619
Uniprot IDs		P21917	B4DKY1 B4DPV7 P49589
PDB IDs		5WIU 5WIV	Not available
GO Terms Enriched among Interactors		D2 Dopamine Receptor Binding Adenylate Cyclase Binding Response To Forskolin Cellular Response To Forskolin Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ephrin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Chloride Channel Complex Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Molecular Condensate Scaffold Activity D4 Dopamine Receptor Binding Nucleotide Binding Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Biological Quality Regulation Of Organelle Organization Beta2-adrenergic Receptor Activity Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation GABA Receptor Complex Chloride Channel Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation D3 Dopamine Receptor Binding Ethanolamine Kinase Activity	Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Postsynapse Protein Metabolic Process Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Neurotransmitter Uptake Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Response To Interleukin-1 Adult Locomotory Behavior Regulation Of Purine Nucleotide Metabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Response To Other Organism Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Adult Behavior Cellular Response To Norepinephrine Stimulus Defense Response Response To External Biotic Stimulus Regulation Of System Process Growth Factor Receptor Binding