DRD4 and KCNJ9

Number of citations: 0 (PubMedID 12297500)
Data Source: HPRD (in vitro, in vivo)

		DRD4	KCNJ9
Name		dopamine receptor D4	potassium inwardly rectifying channel subfamily J member 9
Structure
GO Annotations	Cellular Component	Centrosome Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Inward Rectifier Potassium Channel Complex
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity Ligand-gated Monoatomic Cation Channel Activity
	Biological Process	Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Adult Behavior Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonate Secretion Negative Regulation Of Protein Secretion Regulation Of Transport Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential Potassium Ion Import Across Plasma Membrane
Pathways		Dopamine receptors G alpha (i) signalling events	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Nandrolone decanoate Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil	Ethanol Isavuconazole
GWAS		No GWAS studies recorded	Alcohol consumption over the past year ( 29058377 )
Interacting Genes		9 interacting genes: ADCY2 ADRB2 CLIC6 GABRA1 GNAI1 GRB2 KCNJ9 KLHL12 NCK1	6 interacting genes: ADRB2 DRD2 DRD4 KCNJ3 KCNJ6 TMEM201
Entrez ID		1815	3765
HPRD ID		00541	02959
Ensembl ID		ENSG00000069696	ENSG00000162728
Uniprot IDs		P21917	Q92806
PDB IDs		5WIU 5WIV	6X23
GO Terms Enriched among Interactors		D2 Dopamine Receptor Binding Adenylate Cyclase Binding Response To Forskolin Cellular Response To Forskolin Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ephrin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Chloride Channel Complex Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Molecular Condensate Scaffold Activity D4 Dopamine Receptor Binding Nucleotide Binding Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Biological Quality Regulation Of Organelle Organization Beta2-adrenergic Receptor Activity Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation GABA Receptor Complex Chloride Channel Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation D3 Dopamine Receptor Binding Ethanolamine Kinase Activity	Potassium Channel Regulator Activity Norepinephrine Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission G-protein Activated Inward Rectifier Potassium Channel Activity Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Binding Positive Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Behavioral Response To Ethanol Response To Histamine Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Arachidonate Secretion G Protein-coupled Dopamine Receptor Signaling Pathway Inward Rectifier Potassium Channel Activity Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To Amphetamine Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Temperature Homeostasis Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Transport Potassium Ion Import Across Plasma Membrane Response To Amine Negative Regulation Of Blood Pressure Long-chain Fatty Acid Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Smooth Muscle Contraction Monoatomic Ion Transport Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Activity Regulation Of Sodium Ion Transport Negative Regulation Of Protein Secretion Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Receptor Internalization Intracellular Monoatomic Cation Homeostasis Regulation Of Amine Transport Voltage-gated Potassium Channel Complex Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis