DRD4 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 18303015)
39

Data Source:
HPRD (two hybrid, in vivo)

		DRD4	KLHL12
Description		dopamine receptor D4	kelch like family member 12
Image
GO Annotations	Cellular Component	Centrosome Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Adult Behavior Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonate Secretion Negative Regulation Of Protein Secretion Regulation Of Transport Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating
Pathways		Dopamine receptors G alpha (i) signalling events	Degradation of DVL
Drugs		Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Nandrolone decanoate Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS
Interacting Genes		9 interacting genes: ADCY2 ADRB2 CLIC6 GABRA1 GNAI1 GRB2 KCNJ9 KLHL12 NCK1	58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		1815	59349
HPRD ID		00541	13925
Ensembl ID		ENSG00000069696	ENSG00000117153
Uniprot IDs		P21917	Q53G59 Q9H7R2
PDB IDs		5WIU 5WIV	2VPJ 6TTK 6V7O 8OIO 8RBH
Enriched GO Terms of Interacting Partners?		D2 Dopamine Receptor Binding Adenylate Cyclase Binding Response To Forskolin Cellular Response To Forskolin Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ephrin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Chloride Channel Complex Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Molecular Condensate Scaffold Activity D4 Dopamine Receptor Binding Nucleotide Binding Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Biological Quality Regulation Of Organelle Organization Beta2-adrenergic Receptor Activity Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation GABA Receptor Complex Chloride Channel Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation D3 Dopamine Receptor Binding Ethanolamine Kinase Activity	Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion
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