PEX3

Description		peroxisomal biogenesis factor 3
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GO Annotations	Cellular Component	Nucleoplasm Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Protein-containing Complex Protein-lipid Complex
	Molecular Function	Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity
	Biological Process	Peroxisome Organization Protein Import Into Peroxisome Membrane
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Skin aging measurement ( 31522824)
Novel Interacting Genes		2 novel interacting genes: SHANK2 WT1
Interacting Genes		2 interacting genes: PEX16 PEX19
Entrez ID		8504
HPRD ID		04407
Ensembl ID		ENSG00000034693
Uniprot IDs		P56589
PDB IDs		3AJB 3MK4
Enriched GO Terms of Interacting Partners?		Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Membrane Membrane Biogenesis Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Brush Border Membrane Peroxisomal Membrane Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization Peroxisome Peroxisome Membrane Targeting Sequence Binding Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Protein Targeting Establishment Of Protein Localization To Membrane Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Synaptic Receptor Adaptor Activity Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Protein To Membrane Docking S-shaped Body Morphogenesis Regulation Of Female Gonad Development Metanephric Mesenchyme Development Protein Localization To Membrane Diaphragm Development Positive Regulation Of Male Gonad Development Cardiac Muscle Cell Fate Commitment Establishment Of Protein Localization To Organelle Protein Carrier Chaperone Peroxisome Fission Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Neurofilament Podocyte Differentiation Nephron Tubule Morphogenesis Muscle Cell Fate Commitment C2H2 Zinc Finger Domain Binding Protein Import Into Peroxisome Matrix Metanephric Epithelium Development
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