ELAVL1 and HOTAIR

Number of citations of the paper that reports this interaction (PubMedID 24326307)
39

Data Source:
BioGRID (unspecified method)

		ELAVL1	HOTAIR
Description		ELAV like RNA binding protein 1	HOX transcript antisense RNA
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Sarcoplasm Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity LncRNA Binding
	Biological Process	LncRNA-mediated Post-transcriptional Gene Silencing Protein Import Into Nucleus Cell Population Proliferation Response To Glucose Positive Regulation Of Autophagy Post-transcriptional Gene Silencing Positive Regulation Of Superoxide Anion Generation Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Autophagosome Size MRNA Stabilization Protein Homooligomerization Negative Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways		HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		44 interacting genes: AKT1 ANP32A ANP32B APOE C12orf75 CARM1 CEBPA CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL6 IL7R KPNA1 KPNB1 LINC00460 LINC00632 MIRLET7B MIRLET7I NEIL3 NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA	5 interacting genes: AR ATXN1 DZIP3 ELAVL1 EZH2
Entrez ID		1994	100124700
HPRD ID		16025
Ensembl ID		ENSG00000066044	ENSG00000228630
Uniprot IDs		Q15717
PDB IDs		3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Import Signal Receptor Activity Regulation Of Signal Transduction Regulation Of Platelet Activation Nuclear Localization Sequence Binding Regulation Of Macromolecule Metabolic Process Stress Granule Disassembly Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Blood Coagulation Positive Regulation Of Catabolic Process Intracellular Signaling Cassette Regulation Of Fat Cell Differentiation Regulation Of Hemostasis Regulation Of Wound Healing Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Response To Wounding Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway LncRNA Binding Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Induction Negative Regulation Of RNA Metabolic Process Chromatin Binding Male Somatic Sex Determination Positive Regulation Of Autophagosome Size RNA Binding Hepatocyte Homeostasis Regulation Of Gliogenesis Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Cellular Response To Trichostatin A Negative Regulation Of Macromolecule Biosynthetic Process Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Cell Differentiation Positive Regulation Of Integrin Biosynthetic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Autophagosome Size Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane POZ Domain Binding Positive Regulation Of Cell Population Proliferation Androgen Binding Negative Regulation Of Biosynthetic Process LncRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Prostatic Bud Formation Regulation Of Developmental Process Postsynapse Histone H3K27 Methyltransferase Activity RNA Polymerase II General Transcription Initiation Factor Binding Cellular Response To Testosterone Stimulus Nuclear Transport Nucleocytoplasmic Transport Pronucleus Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Cerebellar Cortex Development Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Poly(G) Binding Lateral Sprouting From An Epithelium Epithelial Cell Differentiation Involved In Prostate Gland Development Primary MiRNA Binding
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