ELAVL1 and PTGS2

Number of citations of the paper that reports this interaction (PubMedID 22544606)
48

Data Source:
BioGRID (unspecified method, affinity chromatography technology, unspecified method)

		ELAVL1	PTGS2
Description		ELAV like RNA binding protein 1	prostaglandin-endoperoxide synthase 2
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Sarcoplasm Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Neuron Projection
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity LncRNA Binding	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	LncRNA-mediated Post-transcriptional Gene Silencing Protein Import Into Nucleus Cell Population Proliferation Response To Glucose Positive Regulation Of Autophagy Post-transcriptional Gene Silencing Positive Regulation Of Superoxide Anion Generation Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Autophagosome Size MRNA Stabilization Protein Homooligomerization Negative Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Embryo Implantation Regulation Of Blood Pressure Response To Nematode Response To Selenium Ion Positive Regulation Of Vascular Endothelial Growth Factor Production Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Prostaglandin Secretion Regulation Of Cell Population Proliferation Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Decidualization Regulation Of Inflammatory Response Brown Fat Cell Differentiation Cellular Response To Hypoxia Cellular Response To Non-ionic Osmotic Stress Cellular Response To Fluid Shear Stress Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Pathways		HuR (ELAVL1) binds and stabilizes mRNA	Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs			Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols
Diseases			Esophageal cancer Penile cancer Cholangiocarcinoma
GWAS			Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)
Interacting Genes		44 interacting genes: AKT1 ANP32A ANP32B APOE C12orf75 CARM1 CEBPA CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL6 IL7R KPNA1 KPNB1 LINC00460 LINC00632 MIRLET7B MIRLET7I NEIL3 NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA	13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22
Entrez ID		1994	5743
HPRD ID		16025	02599
Ensembl ID		ENSG00000066044	ENSG00000073756
Uniprot IDs		Q15717	P35354
PDB IDs		3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3	5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Import Signal Receptor Activity Regulation Of Signal Transduction Regulation Of Platelet Activation Nuclear Localization Sequence Binding Regulation Of Macromolecule Metabolic Process Stress Granule Disassembly Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Blood Coagulation Positive Regulation Of Catabolic Process Intracellular Signaling Cassette Regulation Of Fat Cell Differentiation Regulation Of Hemostasis Regulation Of Wound Healing Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Response To Wounding Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity	Negative Regulation Of Nitric Oxide Biosynthetic Process Enzyme Binding Regulation Of Fibroblast Proliferation Regulation Of Post-translational Protein Modification Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Protein Deneddylation Regulation Of Cellular Response To Growth Factor Stimulus Apoptotic Signaling Pathway MRNA 3'-UTR Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Neddylation Protein Modification By Small Protein Removal Protein Neddylation Glandular Epithelial Cell Differentiation Disordered Domain Specific Binding Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Oxygen Levels Regulation Of Post-transcriptional Gene Silencing Negative Regulation Of Fibroblast Proliferation COP9 Signalosome Regulation Of Programmed Necrotic Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Fibroblast Proliferation Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Telomere Maintenance Via Telomerase Regulation Of Calcium Ion Import Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Negative Regulation Of Gliogenesis Neuroblast Proliferation Positive Regulation Of Programmed Cell Death Regulation Of Calcium Ion Transport Negative Regulation Of Epithelial Cell Differentiation Gastrulation Inward Rectifier Potassium Channel Inhibitor Activity Basolateral Plasma Membrane Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Autophagosome Size Prostaglandin-I Synthase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of RNA Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
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