ELAVL1 and PTGS2

Number of citations of the paper that reports this interaction (PMID 17383427)
30

Data Source:
BioGRID (unspecified method, affinity chromatography technology, unspecified method)

		ELAVL1	PTGS2
Gene Name		ELAV like RNA binding protein 1	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Caveola Neuron Projection Protein Complex
	Molecular Function	Nucleotide Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding AU-rich Element Binding Protein Kinase Binding MRNA 3'-UTR AU-rich Region Binding Poly(A) RNA Binding	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Lipid Binding Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Arachidonate 15-lipoxygenase Activity
	Biological Process	Multicellular Organismal Development Gene Expression Positive Regulation Of Translation MRNA Stabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Maintenance	Prostaglandin Biosynthetic Process Angiogenesis Prostaglandin Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Movement Of Cell Or Subcellular Component Inflammatory Response Response To Oxidative Stress Embryo Implantation Learning Memory Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Fructose Response To Manganese Ion Response To Lithium Ion Positive Regulation Vascular Endothelial Growth Factor Production Sensory Perception Of Pain Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Lipoxygenase Pathway NAD Metabolic Process Bone Mineralization Ovulation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Response To Lipopolysaccharide Response To Vitamin D Response To Tumor Necrosis Factor Cellular Response To UV Maintenance Of Blood-brain Barrier Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Hair Cycle Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Vasoconstriction Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Decidualization Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Oxidation-reduction Process Response To Fatty Acid Cellular Response To Mechanical Stimulus Cellular Response To ATP Cellular Response To Hypoxia Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements HuR stabilizes mRNA	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Nicotinamide salvaging Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Synthesis of 15-eicosatetraenoic acid derivatives Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism
Drugs			gamma-Homolinolenic acid Icosapent Aminosalicylic Acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicyclic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salicylate-sodium Salsalate Trisalicylate-choline Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic Acid Resveratrol Heme 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic Acid Nimesulide Lornoxicam Nepafenac Pomalidomide
Diseases
GWAS			Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		35 interactors: ANP32A ANP32B APOE CARM1 CELF2 CHEK2 CTNNB1 ERG GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP1 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VEGFA XIAP	11 interactors: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 NUCB1 PTGIS TP53
Entrez ID		1994	5743
HPRD ID		16025	02599
Ensembl ID		ENSG00000066044	ENSG00000073756
Uniprot IDs		B4DVB8 Q15717	P35354
PDB IDs		3HI9 4ED5 4EGL 4FXV	1V0X
Enriched GO Terms of Interacting Partners?		Regulation Of Wound Healing Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Positive Regulation Of Transport Negative Regulation Of Wound Healing Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Protein Metabolic Process Cell Death Death Regulation Of Platelet Activation Regulation Of Metabolic Process Cell Communication Signal Transduction Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Ion Transport Regulation Of Nitrogen Compound Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Receptor Activity Signaling Response To Abiotic Stimulus Blood Coagulation Negative Regulation Of Platelet Activation Hemostasis Regulation Of Epithelial Cell Migration Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Stimulus Regulation Of Apoptotic Process Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Organic Substance Regulation Of Cell Death Response To Wounding Blood Circulation Response To Cytokine Execution Phase Of Apoptosis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Migration Vasculature Development RNA Splicing Regulation Of Peptidyl-tyrosine Phosphorylation	Negative Regulation Of Reactive Oxygen Species Metabolic Process Cullin Deneddylation Protein Deneddylation Cellular Response To Oxygen Levels Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Calcium Ion Import Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Calcium Ion Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Ischemia Positive Regulation Of Cell Death Negative Regulation Of Cell Proliferation Regulation Of Neuroblast Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Epithelial Cell Proliferation Response To Hypoxia Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Lactation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Reactive Oxygen Species Biosynthetic Process Apoptotic Signaling Pathway Positive Regulation Of Histone Modification Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ion Transmembrane Transport Cell Death Protein Oligomerization Death Canonical Wnt Signaling Pathway Positive Regulation Of Calcium Ion Transport Vasculogenesis Response To Abiotic Stimulus Regulation Of Fibroblast Proliferation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromitophagy Negative Regulation Of Mitotic Cell Cycle, Embryonic
Tagcloud ?		bace1 bingo cdk2 clustering criterion cytoscape degs downloaded glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plp1 plug software string webgestalt wee1	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation foxo3 infiltrating let lungs mir mirna orchestrating participating pertaining poisoning runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Difference) ?		bace1 bingo cdk2 clustering criterion cytoscape degs downloaded glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plp1 plug software string webgestalt wee1	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation foxo3 infiltrating let lungs mir mirna orchestrating participating pertaining poisoning runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Intersection) ?